2023
Combining Pharmacotherapy and Psychological Treatments for Obsessive-Compulsive Disorder
Tolin D, Sain K. Combining Pharmacotherapy and Psychological Treatments for Obsessive-Compulsive Disorder. 2023, 557-583. DOI: 10.1093/oxfordhb/9780190068752.013.21.Peer-Reviewed Original ResearchCognitive behavioral therapyObsessive-compulsive disorderD-cycloserineFirst-line monotherapyEffective monotherapyCombined therapyMedication monotherapyMonotherapyFirst treatmentSystematic reviewCBT monotherapyTherapyPsychological treatmentCompulsive disorderPharmacotherapyTreatmentMeta-analytic strategyBiological mechanismsDisordersEfficacyPlaceboMedicationsPatients
2022
Central and peripheral nervous system responses to chronic and paced hyperventilation in anxious and healthy subjects
Tolin D, O'Bryan E, Davies C, Diefenbach G, Johannesen J. Central and peripheral nervous system responses to chronic and paced hyperventilation in anxious and healthy subjects. Biological Psychology 2022, 176: 108472. PMID: 36481266, PMCID: PMC9839632, DOI: 10.1016/j.biopsycho.2022.108472.Peer-Reviewed Original ResearchConceptsAnxious patientsCentral nervous system correlatesPeripheral nervous system responsesAlpha-1 powerPeripheral nervous systemFurther treatment developmentNervous system responsesHealthy control participantsHypocapnic patientsNormocapnic patientsChronic hyperventilationRespiratory distressEEG abnormalitiesHealthy subjectsSkin conductance levelNervous systemPatientsControl groupHealthy participantsPoor toleranceTreatment developmentSkin conductance response amplitudeControl participantsBreathing taskMechanistic target
2021
Psychophysiological assessment of stress reactivity and recovery in anxiety disorders
Tolin DF, Lee E, Levy HC, Das A, Mammo L, Katz BW, Diefenbach GJ. Psychophysiological assessment of stress reactivity and recovery in anxiety disorders. Journal Of Anxiety Disorders 2021, 82: 102426. PMID: 34022509, DOI: 10.1016/j.janxdis.2021.102426.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderCognitive behavioral therapyAnxiety disordersPanic disorderStressor phaseCBT outcomeHigh-frequency heart rate variabilityFrequency heart rate variabilityPsychophysiological reactivityEnd-tidal CODSM-5 anxiety disordersSpecialty outpatient clinicsHealthy control participantsHeart rate variabilityAdult patientsOutpatient clinicRate recoveryPatientsReactivity phaseResting phaseAnxious patientsAutonomic recoveryRate variabilityControl participantsDiminished changes
2018
An Evaluation of the Effectiveness of a Transdiagnostic Bibliotherapy Program for Anxiety and Related Disorders: Results From Two Studies Using a Benchmarking Approach
Wootton B, Steinman S, Czerniawski A, Norris K, Baptie C, Diefenbach G, Tolin D. An Evaluation of the Effectiveness of a Transdiagnostic Bibliotherapy Program for Anxiety and Related Disorders: Results From Two Studies Using a Benchmarking Approach. Cognitive Therapy And Research 2018, 42: 565-580. DOI: 10.1007/s10608-018-9921-x.Peer-Reviewed Original ResearchCognitive behavior therapyGroup effect sizesRelated disordersPrimary outcome measureEvidence-based treatmentsTreatment of anxietyMixed anxiety disordersEffect sizeFirst studyOpen trialOutcome measuresEffective treatmentStudy participantsAnxiety disordersDisordersBehavior therapyTreatmentPatientsSignificant reductionInterventionFollowAnxietyTrialsPreliminary supportParticipants
2017
An open trial of cognitive behavioral therapy with contingency management for hoarding disorder
Worden B, Bowe W, Tolin D. An open trial of cognitive behavioral therapy with contingency management for hoarding disorder. Journal Of Obsessive-Compulsive And Related Disorders 2017, 12: 78-86. DOI: 10.1016/j.jocrd.2016.12.005.Peer-Reviewed Original ResearchCognitive behavioral therapyOpen trialContingency managementBehavioral therapyTrials of CBTCurrent open trialCognitive-behavioral group therapyAdjunctive interventionSignificant symptomsEffective treatmentCBT groupLarge effect sizesHome clutterRating ScaleClutter Image Rating ScaleTherapySubstance useSymptomsMixed effects modelsGroup therapyMost participantsTrialsPatientsSignificant reductionEffect size
2014
Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study
DiMauro J, Genova M, Tolin D, Kurtz M. Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study. Journal Of Obsessive-Compulsive And Related Disorders 2014, 3: 132-138. DOI: 10.1016/j.jocrd.2014.03.006.Peer-Reviewed Original ResearchCognitive remediationRelaxation control conditionComputer-assisted cognitive remediationControl conditionCognitive behavioral therapyExecutive functioningAttentional impairmentCognitive functioningHoarding DisorderNeuropsychological impairmentCognitive functionFuture researchFunctioningLarge sample studiesImpairmentDisordersBlinded assessmentStandardized programAttentionMemoryPilot studySample studyParticipantsPatientsSessions
2012
D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report
Norberg M, Gilliam C, Villavicencio A, Pearlson G, Tolin D. D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report. Cognitive And Behavioral Practice 2012, 19: 338-345. DOI: 10.1016/j.cbpra.2011.05.002.Peer-Reviewed Original ResearchObsessive-compulsive disorderN-methyl-D-aspartate (NMDA) receptor partial agonist D-cycloserinePartial agonist D-cycloserineThird of patientsD-cycloserineCourse of ERPReuptake inhibitorsCase reportTreatment nonrespondersEffective treatmentPatientsPrior treatmentResponse preventionGreater reductionTreatmentDisordersPresent studyAdequate responseNonrespondersPrevention
2007
1 Contamination and Decontamination
Tolin D, Meunier S. 1 Contamination and Decontamination. 2007, 3-18. DOI: 10.1016/b978-008044701-8/50002-4.Peer-Reviewed Original ResearchContamination-related obsessive-compulsive disorderObsessive-compulsive disorderContamination-related OCD symptomsForms of OCDMost treatment outcome studiesExposure-based treatmentsRole of disgustTreatment outcome studiesContamination fearSpecific fearsOCD symptomsMagic beliefsHabituation responseDisgustFearVague senseBeliefsDistressCompulsionStrong responseTreatment responsePatientsIndividualsDisordersRevulsion
2005
Stepped care for obsessive-compulsive disorder: A pilot study
Tolin D, Diefenbach G, Maltby N, Hannan S. Stepped care for obsessive-compulsive disorder: A pilot study. Cognitive And Behavioral Practice 2005, 12: 403-414. DOI: 10.1016/s1077-7229(05)80068-9.Peer-Reviewed Original ResearchObsessive-compulsive disorderFirst-line psychosocial treatmentPilot studyOCD patientsPercent of patientsClinical decision-making processIntensive treatment optionsEX/RPEX/RP treatmentCost-effectiveness analysisCognitive behavioral therapyResponder criteriaCare protocolsLow-intensity treatmentTreatment optionsPatient responseTreat samplePsychosocial treatmentsPatientsSymptom reductionBrief educationRitual preventionCostly treatmentExposure exercisesTreatment completers
2004
Irritable bowel syndrome: associated features and the efficacy of psychosocial treatments
Olatunji B, Tolin D, Lohr J. Irritable bowel syndrome: associated features and the efficacy of psychosocial treatments. Applied And Preventive Psychology 2004, 11: 125-140. DOI: 10.1016/j.appsy.2004.09.003.Peer-Reviewed Original ResearchIrritable bowel syndromePsychosocial treatmentsEtiology of IBSFeatures of IBSStructured psychosocial treatmentsChronic gastrointestinal disordersIllness-related behaviorsNon-specific factorsBowel syndromeGastrointestinal disordersSevere traumaDemonstrated efficacyPsychiatric symptomsSpecific efficacyTreatment factorsPhysical discomfortAssociated featuresEfficacyTreatmentNon-specific treatment factorsSymptomsPhysiological symptomsDisordersAvailable researchPatients