2010
Grand Challenge Commentary: Synthetic immunology to engineer human immunity
Spiegel DA. Grand Challenge Commentary: Synthetic immunology to engineer human immunity. Nature Chemical Biology 2010, 6: 871-872. PMID: 21079593, DOI: 10.1038/nchembio.477.Peer-Reviewed Original Research
2009
An Antibody-Recruiting Small Molecule That Targets HIV gp120
Parker CG, Domaoal RA, Anderson KS, Spiegel DA. An Antibody-Recruiting Small Molecule That Targets HIV gp120. Journal Of The American Chemical Society 2009, 131: 16392-16394. PMID: 19839582, PMCID: PMC2783809, DOI: 10.1021/ja9057647.Peer-Reviewed Original ResearchConceptsVirus entryComplement-mediated destructionNew treatment strategiesAntibody-recruiting small moleculeAnti-HIV activityHIV/AIDSViral glycoprotein gp120Env-expressing cellsHuman immune systemHuman T cellsSurface viral glycoproteinsHIV treatmentTreatment strategiesHIV survivalT cellsNovel small moleculesHIV gp120Glycoprotein gp120Immune systemGp120Virus replicationAntibodiesGlobal pandemicViral glycoproteinsVirus particles