1996
Autologous granulosa cell coculture demonstrates zygote suppression of granulosa cell steroidogenesis**Presented in part at the 51st Annual Meeting of the American Society for Reproductive Medicine. Seattle, Washington, October 7 to 12, 1995.††Supported in part by Physician Scientist Award (AG00566 [D.B.S.] and R01HD31894 [A.L.S.]) from the National Institutes of Health, National Institute on Aging, Bethesda, Maryland.
Seifer D, Freeman M, Gardiner A, Hill G, Schneyer A, Vanderhyden B. Autologous granulosa cell coculture demonstrates zygote suppression of granulosa cell steroidogenesis**Presented in part at the 51st Annual Meeting of the American Society for Reproductive Medicine. Seattle, Washington, October 7 to 12, 1995.††Supported in part by Physician Scientist Award (AG00566 [D.B.S.] and R01HD31894 [A.L.S.]) from the National Institutes of Health, National Institute on Aging, Bethesda, Maryland. Fertility And Sterility 1996, 66: 425-429. PMID: 8751742, DOI: 10.1016/s0015-0282(16)58513-6.Peer-Reviewed Original ResearchConceptsLuteinized granulosa cellsGranulosa cellsStandard IVF-ET treatment cycleIVF-ET treatment cyclesTwo-pronuclear embryosGranulosa cell steroidogenesisTwo-pronuclear zygotesNational InstituteVitro Fertilization UnitProduction of E2Steroid hormone productionPituitary desensitizationOvarian stimulationFollicular aspiratesCell steroidogenesisFertilization unitTreatment cyclesHormone productionCell coculturesReproductive medicineP productionAmerican SocietyAcademic research environmentE2Human embryos
1994
Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist-induced suppression is associated with impaired implantation**Presented at the 48th Annual Meeting of The American Fertility Society, New Orleans, Louisiana, November 2 to 5, 1992.
Penzias A, Lee G, Seifer D, Shamma F, DeCherney A, Reindollar R, Jones E. Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist-induced suppression is associated with impaired implantation**Presented at the 48th Annual Meeting of The American Fertility Society, New Orleans, Louisiana, November 2 to 5, 1992. Fertility And Sterility 1994, 61: 558-560. PMID: 8137986, DOI: 10.1016/s0015-0282(16)56595-9.Peer-Reviewed Original ResearchConceptsAmerican Fertility SocietyBioactive LHDelayed suppressionImpairs implantationOvarian suppressionPituitary suppressionCycle outcomePrognostic markerE2 responseFertility SocietyE2 productionAberrant riseGnRHFurther studiesPrevious reportsRapid suppressionImplantationSuppressionAnnual MeetingLH
1992
Flow cytometric analysis of deoxyribonucleic acid in human granulosa cells as a function of chronological age and ovulation induction regimen
Seifer DB, Honig J, Penzias AS, Lavy G, Nadkarni PM, Jones EE, DeCherney AH, Flynn SD. Flow cytometric analysis of deoxyribonucleic acid in human granulosa cells as a function of chronological age and ovulation induction regimen. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 636-640. PMID: 1639962, DOI: 10.1210/jcem.75.2.1639962.Peer-Reviewed Original ResearchConceptsHuman menopausal gonadotropinOvulation induction regimenGreater proliferative indexInduction regimenLeuprolide acetateProliferative indexGranulosa cellsGroup IGroup IIGroup IIIAmpules of hMGFunction of ageFlow cytometryDay of hCGProspective cohort studyGroup of patientsHuman granulosa cellsChronological ageMenopausal gonadotropinCohort studyOvulation inductionSerum FSHSignificant independent influenceOutcome measuresWomen's age
1991
Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success**Presented in part at the Society for Gynecologic Investigation, San Antonio, Texas, March 20 to 23, 1991.
Seifer D, Thornton K, DeCherney A, Lavy G. Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success**Presented in part at the Society for Gynecologic Investigation, San Antonio, Texas, March 20 to 23, 1991. Fertility And Sterility 1991, 56: 500-504. PMID: 1909977, DOI: 10.1016/s0015-0282(16)54548-8.Peer-Reviewed Original ResearchConceptsLeuprolide acetatePituitary desensitizationOvarian suppressionPregnancy ratePg/Group IOvarian hyperstimulationIVF-ETE2 responseGroup IIHuman menopausal gonadotropinControlled ovarian hyperstimulationFertilization-embryo transferSerum estradiol levelsNumber of oocytesHuman chorionic gonadotropinHigher pregnancy ratePg/mLMenopausal gonadotropinIVF patientsRetrospective seriesEstradiol levelsGynecologic InvestigationInfertility practiceMenstrual cycle