2022
Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupInsulin resistanceMenstrual patternAdolescent femalesControl groupRetrospective case-control studyLarge-scale prospective studiesAcute pelvic painEndometrial stripe thicknessTransabdominal pelvic ultrasoundTertiary children's hospitalPolycystic ovarian syndromeBody mass indexCase-control studyInstitutional review boardAdolescent PCOSEndometrial thicknessPelvic painOvarian syndromePCOS diagnosisPelvic ultrasoundUnique pathophysiologyEndocrinology clinicChildren's HospitalMass index
2013
Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation
Tal R, Seifer DB, Shohat-Tal A, Grazi RV, Malter HE. Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation. Fertility And Sterility 2013, 100: 538-543. PMID: 23684116, DOI: 10.1016/j.fertnstert.2013.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, CDCase-Control StudiesEndoglinFemaleFertilization in VitroFollicular FluidHumansInfertility, FemaleOvarian Hyperstimulation SyndromeOvulation InductionPolycystic Ovary SyndromeReceptors, Cell SurfaceSperm Injections, IntracytoplasmicTransforming Growth Factor beta1UltrasonographyYoung AdultConceptsPolycystic ovarian syndromeSerum soluble endoglinDay of hCGSoluble endoglinFollicular fluidTGF-β1Oocyte retrievalOvarian stimulationHCG administrationControl womenDay 3Pathogenesis of PCOSNon-PCOS control groupProspective case-control studyNon-PCOS controlsSerum TGF-β1Non-PCOS womenPolycystic ovary syndromeTGF-β1 levelsReproductive technology unitCase-control studyGrowth factor-β1Day of retrievalOvarian hyperstimulationOvarian syndrome
2007
Serum müllerian-inhibiting substance in Down's syndrome pregnancies
Seifer DB, MacLaughlin DT, Cuckle HS. Serum müllerian-inhibiting substance in Down's syndrome pregnancies. Human Reproduction 2007, 22: 1017-1020. PMID: 17218369, DOI: 10.1093/humrep/del497.Peer-Reviewed Original ResearchConceptsDown syndrome pregnanciesMüllerian-inhibiting substanceSyndrome pregnanciesUnaffected pregnanciesPregnancy-associated plasma proteinMI levelsMaternal serum levelsSerum MIS levelsWeeks of gestationCase-control studyAntenatal screening programmeAssisted reproduction techniquesMedian valueSerum levelsMIS levelsMaternal ageScreening programPregnancyDown syndromeUnaffected controlsReproduction techniquesSignificant correlationSyndromePlasma proteinsSerum
2001
Contribution of diminished ovarian reserve to hypofertility associated with endometriosis.
Hock DL, Sharafi K, Dagostino L, Kemmann E, Seifer DB. Contribution of diminished ovarian reserve to hypofertility associated with endometriosis. The Journal Of Reproductive Medicine 2001, 46: 7-10. PMID: 11209637.Peer-Reviewed Original ResearchConceptsStage III/IV endometriosisStage I/II endometriosisOvarian reserveFSH levelsFertilization/embryo transferHigh E2 levelsStage of endometriosisDay 3 levelsMale factor infertilityCase-control studyAge-matched controlsFactor infertilityE2 levelsEndometriosisEmbryo transferTotal groupProgressive lossControl levelsWomenSignificant differencesE2FSHLevelsPatientsInfertility
1999
Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone
Seifer D, Scott R, Bergh P, Abrogast L, Friedman C, Mack C, Danforth D. Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone. Fertility And Sterility 1999, 72: 63-65. PMID: 10428149, DOI: 10.1016/s0015-0282(99)00193-4.Peer-Reviewed Original ResearchConceptsSerum inhibin B levelsInhibin B levelsDay 3 FSH levelsCycle cancellation rateClinical pregnancy rateSerum inhibin BOvarian reserveFSH levelsB levelsInhibin BPregnancy rateCancellation rateDay 3 follicle-stimulating hormoneDay 3 serum FSH levelsHigher cycle cancellation rateTertiary-care fertility centreNumber of ampulesSerum FSH levelsSerum FSH concentrationsFollicle-stimulating hormoneCase-control studyNumber of oocytesOvarian responsivenessFSH concentrationsGonadotropin requirements
1996
Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies*†*Presented in part at the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, Illinois, March 15 to 18, 1995.†Supported in part by Physician Scientist Award from National Institutes of Health, National Institute on Aging grant AG00566 (D.B.S.) and HD29164 (G.M.L.M., A.L.S.).
Seifer D, Lambert-Messerlian G, Canick J, Frishman G, Schneyer A. Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies*†*Presented in part at the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, Illinois, March 15 to 18, 1995.†Supported in part by Physician Scientist Award from National Institutes of Health, National Institute on Aging grant AG00566 (D.B.S.) and HD29164 (G.M.L.M., A.L.S.). Fertility And Sterility 1996, 65: 667-669. PMID: 8774307, DOI: 10.1016/s0015-0282(16)58174-6.Peer-Reviewed Original ResearchConceptsIntrauterine pregnancySerum inhibin concentrationsDimeric inhibinInhibin concentrationsTotal inhibinMaternal serumSerum samplesDimeric inhibin concentrationSingle intrauterine pregnancySerum inhibin levelsCase-control studyAcademic clinical practiceNational InstituteAlpha-inhibin subunitGynecological InvestigationInhibin levelsSonographic evidenceGestational ageInhibin subunitsWeek 8MAIN OUTCOMEClinical practiceInhibinEctopicWomen
1995
Maternal and neonatal morbidity associated with in vitro fertilization
Tallo CP, Vohr B, Oh W, Rubin LP, Seifer DB, Haning RV. Maternal and neonatal morbidity associated with in vitro fertilization. The Journal Of Pediatrics 1995, 127: 794-800. PMID: 7472838, DOI: 10.1016/s0022-3476(95)70175-3.Peer-Reviewed Original ResearchConceptsLow birth weightNeonatal morbidityBirth weightIVF infantsIVF mothersMultiple gestationsControl subjectsLower mean birth weightMore pregnancy-induced hypertensionSingle large teaching hospitalContinuous positive airway pressureMore daysMore perinatal complicationsPregnancy-induced hypertensionPositive airway pressureMean birth weightRespiratory distress syndromePatent ductus arteriosusCase-control studyLarge teaching hospitalDate of deliveryIVF pregnanciesPreterm deliveryAirway pressureLabor induction
1990
Urologic Injury During Vaginal Hysterectomy: A Case-Control Study
ROSENZWEIG B, SEIFER D, GRANT W, RODRIGUEZ F, BIRENBAUM D, ADELSON M. Urologic Injury During Vaginal Hysterectomy: A Case-Control Study. Journal Of Gynecologic Surgery 1990, 6: 27-32. DOI: 10.1089/gyn.1990.6.27.Peer-Reviewed Original ResearchVaginal hysterectomyUrologic injuryCase-control studyRetrospective case-control studyPreoperative diagnostic studiesDistinct risk factorsInadvertent cystotomyBladder injuryUreteral injuryAbdominal surgerySurgical historyRisk factorsOperative techniqueStudy populationHysterectomyUncommon eventInjuryDiagnostic studiesRecent reportsPatientsSurgeryCystotomyIncidence