2018
Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary
Xu J, Lawson MS, Xu F, Du Y, Tkachenko OY, Bishop CV, Pejovic-Nezhat L, Seifer DB, Hennebold JD. Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary. Frontiers In Physiology 2018, 09: 1600. PMID: 30487754, PMCID: PMC6246691, DOI: 10.3389/fphys.2018.01600.Peer-Reviewed Original ResearchVitamin D receptorVitamin D biosynthesisAntral folliclesVD3 supplementationFollicular developmentVitamin DAntral stagePrimate ovaryFollicle survivalVitamin D3D biosynthesisIsolated secondary folliclesOvarian follicle survivalOocyte maturationAnti-Müllerian hormone productionAdult rhesus macaquesParacrine factor productionStage-dependent mannerVD3 treatmentVDR expressionAMH productionDihydroxyvitamin D3Positive immunostainingD receptorProtein localization
2016
Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid, and antimüllerian hormone production
Xu J, Hennebold JD, Seifer DB. Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid, and antimüllerian hormone production. Fertility And Sterility 2016, 106: 1815-1820.e1. PMID: 27678030, PMCID: PMC5136302, DOI: 10.1016/j.fertnstert.2016.08.037.Peer-Reviewed Original ResearchConceptsVitamin D3Follicle survivalPreantral follicle survivalAntral folliclesWeek 5High-dose vitamin D3Direct actionAntimüllerian hormone concentrationsAntral follicle diameterPrimate follicular developmentVitamin D3 actionAntral follicle growthDihydroxy vitamin D3Rhesus monkey ovariesSecondary preantral folliclesFemale rhesus macaquesMacaque folliclesPrimate follicleD3 actionAMH concentrationsNational Primate Research CenterAMH productionPrimate Research CenterFollicle diameterMAIN OUTCOME
2014
Is AMH a regulator of follicular atresia?
Seifer DB, Merhi Z. Is AMH a regulator of follicular atresia? Journal Of Assisted Reproduction And Genetics 2014, 31: 1403-1407. PMID: 25193290, PMCID: PMC4389943, DOI: 10.1007/s10815-014-0328-7.Peer-Reviewed Original ResearchConceptsFollicular atresiaNatural ovarian agingPolycystic ovary syndromeOnset of menopausePremature ovarian insufficiencyTreatment of PCOSDifferent patient populationsBasic science studiesTiming of onsetOvary syndromePatient populationOvarian agingOvarian failureHuman ovaryTreatment strategiesAMH productionOvarian insufficiencyIntraovarian regulatorsGrowth factorCellular originCritical growth factorsCancer therapyMenopauseAtresiaAMH