2017
Podoplanin is a negative regulator of Th17 inflammation
Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. Podoplanin is a negative regulator of Th17 inflammation. JCI Insight 2017, 2: e92321. PMID: 28878118, PMCID: PMC5621890, DOI: 10.1172/jci.insight.92321.Peer-Reviewed Original ResearchConceptsT cellsIL-17IL-17 secretionDistinct cytokine profilesInflammatory gene signatureTh17-polarizing conditionsTh17 cellsCytokine profileCell subsetsInflammatory responseSkin biopsiesMouse modelPDPN expressionMultiple organsSkin diseasesGene signatureInflammationLymphatic systemCLEC-2PDPNRecent dataDifferent subpopulationsCellsTranscriptional profilesShRNA gene
2004
Glutamate Excitotoxicity in Multiple Sclerosis
Pitt D, Raine C. Glutamate Excitotoxicity in Multiple Sclerosis. 2004, 285-303. DOI: 10.1007/978-1-4419-8959-8_16.Peer-Reviewed Original ResearchGlutamate excitotoxicityMultiple sclerosisWhite matter injuryCentral white matterProminent demyelinationMS pathogenesisOligodendrocyte damageInflammatory demyelinationOligodendrocyte lossExtracellular glutamateGlutamate homeostasisAnimal modelsExcitotoxicityWhite matterCell targetsClearance pathwaysCommon pathwayDisease mechanismsCell culture studiesDemyelinationSclerosisRecent dataOligodendrocytesCulture studiesPathogenesis