2015
Analysis of miRNA in Normal Appearing White Matter to Identify Altered CNS Pathways in Multiple Sclerosis
Guerau-de-Arellano M, Liu Y, Meisen WH, Pitt D, Racke MK, Lovett-Racke AE. Analysis of miRNA in Normal Appearing White Matter to Identify Altered CNS Pathways in Multiple Sclerosis. Journal Of Autoimmune Disorders 2015, 1 PMID: 26894232, PMCID: PMC4755487, DOI: 10.21767/2471-8153.100006.Peer-Reviewed Original ResearchCNS pathwaysMS patientsNormal Appearing White MatterBlood-brain barrierMultiple sclerosis susceptibilityPatients' CNSCNS inflammationMultiple sclerosisNeuroprotective mechanismsPost-transcriptional dysregulationControl subjectsUnderlying dysregulationImmune systemWhite matterCNSInflammationMiR-191Target predicationNAWMMiRNA profiling studiesPatientsMRNA analysisMAPK pathwayGenetic contributorsPathway analysis
2000
Glutamate excitotoxicity — a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis?
Werner P, Pitt D, Raine CS. Glutamate excitotoxicity — a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis? Journal Of Neural Transmission. Supplementa 2000, 375-385. PMID: 11205156, DOI: 10.1007/978-3-7091-6301-6_27.Peer-Reviewed Original ResearchConceptsCentral nervous systemAMPA/kainate antagonistMultiple sclerosisGlutamate excitotoxicityImmune cellsKainate antagonistAxonal damageAntigen-primed T cellsMyelin-producing cellsLack of effectSite of entryCNS inflammationInflammatory attacksExperimental autoimmunePerivascular cuffsAutoimmune demyelinationInflammatory lesionsClinical differencesOligodendrocyte survivalEffective therapyGlutamate receptorsOligodendrocyte deathT cellsExcitotoxicityLesion size