2024
Performance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease
Landry M, Hassan S, Rottmann B, Pesak S, Ordazzo M, Skrzyniarz M, Deponte S, Peaper D. Performance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease. Journal Of Clinical Microbiology 2024, 62: e00139-24. PMID: 38597655, PMCID: PMC11077974, DOI: 10.1128/jcm.00139-24.Peer-Reviewed Original ResearchConceptsPositive percent agreementSerologic diagnosis of Lyme diseaseDiagnosis of Lyme diseaseEnzyme-linked immunoassayBorrelia speciesTwo-tier algorithmLyme diseaseTwo-tier testImmunoblottingLaboratory diagnosis of Lyme diseaseLIAISON chemiluminescent immunoassaysChemiluminescence immunoassayDetection of IgMScreening testConsensus reference standardSerological diagnosisLaboratory diagnosisDiaSorinIgM resultsIgM detection
2023
Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age
Merrill A, Durant T, Baron J, Klutts J, Obstfeld A, Peaper D, Stoffel M, Wheeler S, Zaydman M. Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age. Clinical Chemistry 2023, 69: 1333-1341. PMID: 37962514, DOI: 10.1093/clinchem/hvad183.Commentaries, Editorials and LettersEnhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
Moriyama M, Lucas C, Monteiro V, Initiative Y, Iwasaki A, Chen N, Breban M, Hahn A, Pham K, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Vogels C, Grubaugh N. Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2221652120. PMID: 37036977, PMCID: PMC10120007, DOI: 10.1073/pnas.2221652120.Peer-Reviewed Original ResearchConceptsMHC-I expressionBreakthrough infectionsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variantsMajor histocompatibility complex class I expressionCell-mediated immunityInfluenza virus infectionSARS-CoV-2 VOCsMHC-I upregulationClass I expressionSARS-CoV-2T cell recognitionVirus infectionMHC II expressionSpike proteinEnhanced inhibitionInfectionCell recognitionCommon mutationsReinfectionE proteinAntibodiesViral genesSubvariantsExpressionPROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data
Iscoe M, Loza A, Turbiville D, Campbell S, Peaper D, Balbuena-Merle R, Hauser R. PROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data. American Journal Of Clinical Pathology 2023, 160: 98-105. PMID: 37026746, DOI: 10.1093/ajcp/aqad024.Peer-Reviewed Original ResearchConceptsQuality improvement studyElectronic health recordsLaboratory valuesWeb-based clinical decision support toolClinical decision support toolElectronic health record dataHealth record dataImprovement studyResident trainingBlood smear interpretationClinical outcomesMorphologic findingsAcademic hospitalCorresponding reference rangesMedication informationReference rangeMicroscopy findingsCDS toolsIntervention effectsPathology practiceSmear interpretationHealth recordsRecord dataPathologistsPatientsChoice Architecture to Assist Clinicians with Appropriate COVID-19 Test Ordering
Sangal R, Venkatesh A, Cahill J, Pettker C, Peaper D. Choice Architecture to Assist Clinicians with Appropriate COVID-19 Test Ordering. The Journal Of Applied Laboratory Medicine 2023, 8: 98-105. PMID: 36610419, DOI: 10.1093/jalm/jfac104.Peer-Reviewed Original ResearchConceptsRSV testingSymptomatic visitsED visitsSARS-CoV-2 nucleic acid amplification testsCOVID-19Respiratory syncytial virus testingNucleic acid amplification testsElectronic health record ordersSystems-based interventionsSARS-CoV-2Symptomatic patientsPrimary outcomeInfluenza testingClinical guidelinesClinician educationClinician practiceVirus testingAmplification testsPatientsTest orderingInstitutional guidelinesClinical needHospital systemVisitsTesting patterns
2020
Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients
Gaston DC, Malinis M, Osborn R, Peaper DR, Landry M, Juthani-Mehta M, Azar MM. Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients. American Journal Of Transplantation 2020, 21: 1304-1311. PMID: 33043603, PMCID: PMC7675520, DOI: 10.1111/ajt.16357.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsClinical implicationsCycle threshold valuesSOT patientsTransplant recipientsSymptom onsetYale New Haven Health SystemUpper respiratory tract samplesSARS-CoV-2 viral RNASARS-CoV-2 viral dynamicsAdult SOT recipientsRetrospective chart reviewRespiratory tract samplesSARS-CoV-2 cycle threshold valuesInfection prevention measuresCOVID-19 severityViral RNAHigher clinical acuityPrimary diagnostic testRT-PCR assaysSOT recipientsChart reviewViral loadAdmission severity
2018
Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections
Pruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin S, Aronson PL, Collaborative F, Nigrovic L, Browning W, Mitchell C, Peaper D, Feldman E. Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections. The Journal Of Pediatrics 2018, 204: 177-182.e1. PMID: 30297292, PMCID: PMC6309646, DOI: 10.1016/j.jpeds.2018.08.066.Peer-Reviewed Original ResearchConceptsInvasive bacterial infectionsFebrile young infantsAdverse outcomesBacterial meningitisYoung infantsIll appearanceFebrile infantsBacterial infectionsRetrospective cohort studyMedical record reviewLocal microbiology laboratoryMixed-effects logistic regressionElectronic medical record systemDays of ageIll appearingNeurologic sequelaeCohort studyMedical record systemClinical factorsMedication receiptMechanical ventilationRecord reviewClinical dataInclusion criteriaMeningitisEpidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency Departments
Woll C, Neuman MI, Pruitt CM, Wang ME, Shapiro ED, Shah SS, McCulloh RJ, Nigrovic LE, Desai S, DePorre AG, Leazer RC, Marble RD, Balamuth F, Feldman EA, Sartori LF, Browning WL, Aronson PL, Collaborative F, Alpern E, Hayes K, Lee B, Lumb C, Mitchell C, Peaper D, Rooholamini S, Shin S, Williams D. Epidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency Departments. The Journal Of Pediatrics 2018, 200: 210-217.e1. PMID: 29784512, PMCID: PMC6109608, DOI: 10.1016/j.jpeds.2018.04.033.Peer-Reviewed Original ResearchConceptsInvasive bacterial infectionsThird-generation cephalosporinsMicrobiology laboratory databaseEmergency departmentBacterial infectionsBacterial meningitisPediatric emergency departmentCombination of ampicillinAntimicrobial treatment regimenCross-sectional studyGroup B streptococciElectronic medical record systemEmpiric treatmentMedical record systemTreatment regimenChildren's HospitalMost infantsMedical recordsB streptococciCerebrospinal fluidCommon pathogensInfantsAntimicrobial susceptibilityDay oldsInfection
2016
Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients
Green DA, Hitoaliaj L, Kotansky B, Campbell SM, Peaper DR. Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients. Journal Of Clinical Microbiology 2016, 54: 2950-2955. PMID: 27654334, PMCID: PMC5121384, DOI: 10.1128/jcm.01579-16.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmbulatory Care FacilitiesAnti-Bacterial AgentsAsthmaEmergency Service, HospitalFemaleHumansInfluenza, HumanMaleMiddle AgedOrthomyxoviridaeOseltamivirPractice Patterns, Physicians'Pulmonary Disease, Chronic ObstructiveRespiratory Tract InfectionsRetrospective StudiesConceptsNon-influenza virusesRespiratory pathogen testingInfluenza virusAntibiotic prescriptionsPrescription ratesAdult outpatientsLarge Veterans Administration Medical CenterVeterans Administration Medical CenterAntibiotic prescription ratesPathogen testingRespiratory tract infectionsUnnecessary antibiotic useFilmArray Respiratory PanelPatients' medical recordsSpecific therapeutic interventionsTract infectionsRespiratory panelOutpatient centerAntibiotic useAntimicrobial prescriptionsMedical recordsRespiratory pathogensMedical CenterClinical utilityCommon pathogens
2015
The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children
Murray TS, Peaper DR. The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children. Current Opinion In Pediatrics 2015, 27: 124-131. PMID: 25565574, DOI: 10.1097/mop.0000000000000182.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBeta-Lactam ResistanceBeta-LactamasesChildChild, PreschoolCommunity-Acquired InfectionsCross InfectionDrug Resistance, MultipleEscherichia coliEscherichia coli InfectionsGram-Negative Bacterial InfectionsHumansInfantKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsPrevalenceConceptsMultidrug-resistant infectionsGram-negative rodsProlonged fecal carriageAntibiotic prescribing practicesPrevious antibiotic useExtended-spectrum β-lactamasesCommon risk factorsThird-generation cephalosporinsDiagnostic toolAppropriate therapyChallenging infectionsPrescribing practicesNeonatal ICULaboratory criteriaNew diagnostic toolsRisk factorsAntibiotic useFecal carriageCommunity transmissionClinical implicationsInfectionCephalosporin resistanceKlebsiella pneumoniaeReporting criteriaΒ-lactamases
2014
Rapid Diagnosis of Influenza State of the Art
Peaper DR, Landry ML. Rapid Diagnosis of Influenza State of the Art. Clinics In Laboratory Medicine 2014, 34: 365-385. PMID: 24856533, PMCID: PMC7172071, DOI: 10.1016/j.cll.2014.02.009.Peer-Reviewed Original ResearchUse of Imipenem To Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram-Negative Rods in 75 Minutes Using Liquid Chromatography-Tandem Mass Spectrometry
Kulkarni MV, Zurita AN, Pyka JS, Murray TS, Hodsdon ME, Peaper DR. Use of Imipenem To Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram-Negative Rods in 75 Minutes Using Liquid Chromatography-Tandem Mass Spectrometry. Journal Of Clinical Microbiology 2014, 52: 2500-2505. PMID: 24789180, PMCID: PMC4097713, DOI: 10.1128/jcm.00547-14.Peer-Reviewed Original ResearchResponse to Mold Contamination of Intravenous Magnesium Sulfate Produced by a Compounding Pharmacy
Boyce JM, Lee L, Topal J, Peaper DR, Balcezak T. Response to Mold Contamination of Intravenous Magnesium Sulfate Produced by a Compounding Pharmacy. JAMA Internal Medicine 2014, 174: 630-631. PMID: 24493036, DOI: 10.1001/jamainternmed.2013.13772.Peer-Reviewed Original Research
2008
The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading
Peaper DR, Cresswell P. The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 10477-10482. PMID: 18650385, PMCID: PMC2483232, DOI: 10.1073/pnas.0805044105.Peer-Reviewed Original Research