2024
Persistent bloodstream infection in children: examining the role for repeat blood cultures.
Puthawala C, Feinn R, Rivera-Viñas J, Lee H, Murray T, Peaper D. Persistent bloodstream infection in children: examining the role for repeat blood cultures. Journal Of Clinical Microbiology 2024, e0099824. PMID: 39365070, DOI: 10.1128/jcm.00998-24.Peer-Reviewed Original ResearchPositive blood culturesPersistent bloodstream infectionBlood culturesBloodstream infectionsCentral venous catheterPositive culturesVenous cathetersIndex blood cultureCross-sectional study of childrenRepeated blood culturesTime of blood drawElevated inflammatory markersAssociated with persistenceGt;48 hoursIndex cultureCross-sectional studyPersistent bacteremiaImmune dysfunctionPediatric patientsInflammatory markersDiagnostic stewardshipStudy of childrenPatient characteristicsClinical valueBlood draw
2022
195. Reducing Time to Optimal Antimicrobial Therapy (OAT) for Bloodstream Infections (BSI) due to Gram Positive Cocci (GPC) in Chains Using Rapid Diagnostics Paired with Antimicrobial Stewardship (ASP) Efforts
K J, McSweeney T, McManus D, Davis M, Merwede J, Peaper D, Topal J. 195. Reducing Time to Optimal Antimicrobial Therapy (OAT) for Bloodstream Infections (BSI) due to Gram Positive Cocci (GPC) in Chains Using Rapid Diagnostics Paired with Antimicrobial Stewardship (ASP) Efforts. Open Forum Infectious Diseases 2022, 9: ofac492.273. PMCID: PMC9752006, DOI: 10.1093/ofid/ofac492.273.Peer-Reviewed Original ResearchOptimal antimicrobial therapyLength of stayGram-positive cocciBloodstream infectionsASP recommendationsHigher Charlson comorbidity indexMedian LOSCharlson Comorbidity IndexPost-implementation cohortPre-implementation cohortPrimary study endpointRetrospective chart reviewRapid diagnosticsPositive Gram stainYears of ageAntimicrobial stewardship effortsASP interventionsComorbidity indexPrimary endpointBaseline demographicsChart reviewSecondary outcomesStudy endpointPolymicrobial infectionsAntimicrobial therapy535. Evaluation of the BioFire Blood Culture Identification (BCID2) panel for transplant recipients with a bloodstream infection
Palacios C, Peaper D, Malinis M, Malinis M, Perreault S, Cohen E, Vogel J, Azar M. 535. Evaluation of the BioFire Blood Culture Identification (BCID2) panel for transplant recipients with a bloodstream infection. Open Forum Infectious Diseases 2022, 9: ofac492.588. PMCID: PMC9752191, DOI: 10.1093/ofid/ofac492.588.Peer-Reviewed Original ResearchBone marrow transplant recipientsTransplant recipientsBloodstream infectionsBlood culturesPositive blood culturesClinical trialsPrimary investigatorSolid organ recipientsMarrow transplant recipientsRetrospective chart reviewYear of transplantationAntimicrobial susceptibility resultsBlood Culture Identification PanelBSI eventsChart reviewOptimal therapyOrgan recipientsMean ageMultiplex PCR panelSame patientGeneral populationPolymicrobial culturesCandida sppPeripheral sitesRecipients