1998
H-Current Properties of a Neuronal and Network Pacemaker
Lüthi A, McCormick D. H-Current Properties of a Neuronal and Network Pacemaker. Neuron 1998, 21: 9-12. PMID: 9697847, DOI: 10.1016/s0896-6273(00)80509-7.Peer-Reviewed Original Research
1993
A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons
Destexhe A, McCormick D, Sejnowski T. A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophysical Journal 1993, 65: 2473-2477. PMID: 8312485, PMCID: PMC1225988, DOI: 10.1016/s0006-3495(93)81297-9.Peer-Reviewed Original ResearchConceptsReticular cellsReticular thalamic cellsInhibitory postsynaptic potentialsIntrinsic oscillatory propertiesReticularis neuronsSpindle rhythmicityPostsynaptic potentialsInhibitory synapsesThalamic cellsThalamic relayThalamocortical cellsSilent periodSynaptic interactionsSpindle oscillationsRhythmic oscillationsCells
1992
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick D, von Krosigk M. Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2774-2778. PMID: 1313567, PMCID: PMC48745, DOI: 10.1073/pnas.89.7.2774.Peer-Reviewed Original ResearchConceptsSlow-wave sleepCerebral cortexThalamic neuronsRelay neuronsWave sleepLateral geniculate relay neuronsProlonged excitatory postsynaptic potentialGeniculate relay neuronsLayer VI cellsExcitatory postsynaptic potentialsThalamic relay neuronsSensory informationSingle-spike modeBrainstem inputsPostsynaptic potentialsCorticothalamic fibersSlow depolarizationObligatory relayState-dependent mannerSensory transferThalamusMammalian thalamusPotassium conductanceProlonged enhancementNeuronsCellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus
McCormick D. Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. Journal Of Neuroscience 1992, 12: 278-289. PMID: 1309574, PMCID: PMC6575696, DOI: 10.1523/jneurosci.12-01-00278.1992.Peer-Reviewed Original ResearchConceptsInward current responseSlow depolarizationIntracellular recordingsDorsal lateral geniculate neuronsCat LGNdDorsal lateral geniculate nucleusPertussis toxin-insensitive G proteinToxin-insensitive G proteinGABAB agonist baclofenSingle spike activityActivation of muscarinicLateral geniculate neuronsSubpopulation of neuronsApplication of AChApplication of noradrenalineLateral geniculate nucleusRhythmic oscillationsPossible involvementSingle-spike firingThalamocortical relay cellsG proteinsHigh-frequency burstsLGNd neuronsPostsynaptic actionsAgonist baclofen
1989
Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current
Pape H, McCormick D. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature 1989, 340: 715-718. PMID: 2475782, DOI: 10.1038/340715a0.Peer-Reviewed Original ResearchConceptsThalamic neuronsRhythmic burstsAction potentialsHyperpolarization-activated cation currentSingle spike activityGenerate action potentialsSlow-wave sleepSingle-spike firingState of excitabilityAction potential generationSerotonergic inputNeurons displaySynaptic processingSpike activityCation currentThalamic burstsSpike firingNoradrenalineSerotoninCellular mechanismsNeuronsRhythmic oscillationsNovel actionBehavioral statesCyclic AMP
1987
Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones.
McCormick D, Prince D. Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones. The Journal Of Physiology 1987, 393: 743-762. PMID: 2895811, PMCID: PMC1192421, DOI: 10.1113/jphysiol.1987.sp016851.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronesPost-natal developmentImmature neuronesAction potentialsPyramidal neuronesCortical layer V pyramidal neuronsElectrophysiological propertiesRat sensorimotor cortical slicesLayer V pyramidal neuronsDependent action potentialsApparent input resistanceSensorimotor cortical slicesThird week postPyramidal neuronsCortical slicesIntracellular recordingsWeek postCortical neuronesNeuronesInput resistanceAdult neuronesLonger durationSpecific membrane resistanceInward rectificationAge
1986
Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance
McCormick D, Prince D. Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance. Nature 1986, 319: 402-405. PMID: 2418361, DOI: 10.1038/319402a0.Peer-Reviewed Original ResearchConceptsNeuronal activityCholinergic inhibitory mechanismSingle spike activityRole of acetylcholineApplication of acetylcholineCentral nervous systemIntrinsic membrane propertiesAcetylcholine inducesM2 subclassCholinergic actionCholinergic inhibitionCholinergic inputMuscarinic receptorsBurst dischargesExcitatory modulatorThalamic neuronesNervous systemSpike activityFiring patternsPotassium conductanceReticular neuronesAcetylcholineNeuronesReticular systemInhibitory mechanism
1983
Neuronal responses of the rabbit brainstem during performance of the classically conditioned nictitating membrane (NM)/eyelid response
McCormick D, Lavond D, Thompson R. Neuronal responses of the rabbit brainstem during performance of the classically conditioned nictitating membrane (NM)/eyelid response. Brain Research 1983, 271: 73-88. PMID: 6883122, DOI: 10.1016/0006-8993(83)91366-5.Peer-Reviewed Original ResearchConceptsBrainstem nucleiSensory nucleusReticular regionsSuperior colliculusNeuronal responsesLong-term neuronal changesCorneal airpuff unconditioned stimulusEyeblink responseRecent lesion studiesNeuronal unit activityRelated brainstem nucleiUnconditioned stimulusAirpuff unconditioned stimulusNeuronal changesPeriaqueductal grayRabbit brainstemIpsilateral cerebellumFacial nucleusPontine nucleiAuditory nucleiAccessory abducensUnit activityBrainstemLesion studiesCerebellum
1982
Initial localization of the memory trace for a basic form of learning.
McCormick D, Clark G, Lavond D, Thompson R. Initial localization of the memory trace for a basic form of learning. Proceedings Of The National Academy Of Sciences Of The United States Of America 1982, 79: 2731-2735. PMID: 6953427, PMCID: PMC346276, DOI: 10.1073/pnas.79.8.2731.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlinkingCerebellumComputersElectric ConductivityFunctional LateralityLearningMemoryNeuronsRabbitsConceptsNeuronal unit activityEye contralateralReflex responsesIpsilateral cerebellumUnconditioned reflex responseNeuronal plasticityCerebellar lesionsElectrophysiological recordingsUnit activityLateral cerebellumCerebellumTraining trialsBehavioral responsesMarked contrastResponseMembrane responseContralateralLesions