2007
Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo
Haider B, Duque A, Hasenstaub A, Yu Y, McCormick D. Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo. Journal Of Neurophysiology 2007, 97: 4186-4202. PMID: 17409168, DOI: 10.1152/jn.01114.2006.Peer-Reviewed Original ResearchConceptsPostsynaptic potentialsVisual responsivenessSpontaneous depolarizationsNetwork activityNeocortical network activityInhibitory synaptic potentialsPrimary visual cortexLocal network activityAction potential generationContrast response functionsCortical neuronsSynaptic potentialsSynaptic transmissionSpontaneous activityMembrane potential depolarizationKetamine-xylazineExtracellular recordingsVisual cortexAction potentialsLocal circuitsIntegrative propertiesSensory responsesPotential depolarizationSlow oscillationsPotential generation
2004
Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body
Bergsman JB, De Camilli P, McCormick DA. Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body. Journal Of Neurophysiology 2004, 92: 545-552. PMID: 15212444, DOI: 10.1152/jn.00927.2003.Peer-Reviewed Original ResearchConceptsPrincipal cellsTrapezoid bodyElectrophysiological criteriaMedial nucleusNerve terminalsMammalian auditory brain stemExcitatory postsynaptic current amplitudeCalyceal nerve terminalsMouse medial nucleusAuditory brain stemPostsynaptic current amplitudeStrong excitatory inputGiant nerve terminalCalyx of HeldPrincipal neuronsBrain stemExcitatory inputsSynaptic transmissionCentral synapseAnatomical studySynapseSound localizationTransmitter typeCellsCurrent amplitude
1998
The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus
Kim U, McCormick D. The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus. Journal Of Neuroscience 1998, 18: 9500-9516. PMID: 9801387, PMCID: PMC6792899, DOI: 10.1523/jneurosci.18-22-09500.1998.Peer-Reviewed Original ResearchConceptsAction potentialsThalamocortical neuronsPostsynaptic neuronsDorsal lateral geniculate nucleus (dLGN) neuronsLateral geniculate nucleus neuronsDual intracellular recordingsTonic firing modesLow-threshold Ca2Single action potentialHigh-frequency burstsAction potential generationPerigeniculate neuronsTonic trainsCell typesMembrane potentialNucleus neuronsBurst dischargesIntracellular recordingsGeneration of Ca2Synaptic transmissionPresynaptic cellTemporal summationEpileptic seizuresSynchronized rhythmic oscillationsSynaptic interactions
1995
Acetylcholine excites GABAergic neurons of the ferret perigeniculate nucleus through nicotinic receptors
Lee K, McCormick D. Acetylcholine excites GABAergic neurons of the ferret perigeniculate nucleus through nicotinic receptors. Journal Of Neurophysiology 1995, 73: 2123-2128. PMID: 7623105, DOI: 10.1152/jn.1995.73.5.2123.Peer-Reviewed Original ResearchConceptsAction of acetylcholineSingle spike activityPerigeniculate nucleusPGN cellsGABAergic neuronsSpike activityLocal applicationDirect postsynaptic actionFerret thalamic slicesNicotinic antagonist hexamethoniumIntracellular recording techniquesAction potential firingLow-threshold Ca2Slow hyperpolarizing responseVitro. 2Antagonist hexamethoniumMembrane conductancePostsynaptic actionsGABAergic cellsMuscarinic antagonistMuscarinic receptorsDepolarizing responsePGN neuronsHyperpolarizing responseSynaptic transmission
1988
Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro
McCormick D, Prince D. Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro. Journal Of Neurophysiology 1988, 59: 978-996. PMID: 3367206, DOI: 10.1152/jn.1988.59.3.978.Peer-Reviewed Original ResearchConceptsSlow depolarizationElectrophysiological actionsPT neuronsGuinea pigsSlow membrane timeSpike frequency accommodationApplication of norepinephrineSingle spike activityMedial geniculate nucleusExtracellular potassium concentrationCat thalamic neuronsLarge afterhyperpolarizationSlow afterdepolarizationSlow afterhyperpolarizationAnteroventral nucleusCerebral cortexFrequency accommodationThalamic neuronsThalamocortical rhythmsThalamic nucleiGeniculate nucleusIntracellular recordingsNoradrenergic modulationSynaptic transmissionThalamic slices
1987
Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro.
McCormick D, Prince D. Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro. The Journal Of Physiology 1987, 392: 147-165. PMID: 2833597, PMCID: PMC1192298, DOI: 10.1113/jphysiol.1987.sp016774.Peer-Reviewed Original ResearchConceptsRapid excitatory responseSlow depolarizationApplication of acetylcholineLateral geniculate nucleusGeniculate nucleusMuscarinic hyperpolarizationExcitatory responsesMuscarinic receptorsReversal potentialDorsal lateral geniculate nucleusGeniculate neuronesApparent input conductanceSingle spike activityIntracellular recording techniquesAction of acetylcholineACh-induced hyperpolarizationExtrapolated reversal potentialSingle-spike firingMechanism of actionMembrane potentialBath applicationBurst firingBurst dischargesSynaptic transmissionThalamic slices