1992
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick D, von Krosigk M. Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2774-2778. PMID: 1313567, PMCID: PMC48745, DOI: 10.1073/pnas.89.7.2774.Peer-Reviewed Original ResearchConceptsSlow-wave sleepCerebral cortexThalamic neuronsRelay neuronsWave sleepLateral geniculate relay neuronsProlonged excitatory postsynaptic potentialGeniculate relay neuronsLayer VI cellsExcitatory postsynaptic potentialsThalamic relay neuronsSensory informationSingle-spike modeBrainstem inputsPostsynaptic potentialsCorticothalamic fibersSlow depolarizationObligatory relayState-dependent mannerSensory transferThalamusMammalian thalamusPotassium conductanceProlonged enhancementNeurons
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductance
1990
Functional implications of burst firing and single spike activity in lateral geniculate relay neurons
McCormick D, Feeser H. Functional implications of burst firing and single spike activity in lateral geniculate relay neurons. Neuroscience 1990, 39: 103-113. PMID: 2089273, DOI: 10.1016/0306-4522(90)90225-s.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsAction potentialsSingle-spike modeThalamic neuronsPostsynaptic potentialsRelay neuronsRhythmic burstsExcitatory inputsLateral geniculate relay neuronsGeniculate relay neuronsPhasic excitatory inputPeripheral receptive fieldsSingle spike activityPeriods of drowsinessLow-threshold Ca2Slow-wave sleepThalamocortical relay neuronsIncoming excitatory inputsHigh-frequency burstsFiring modesNeuronal activityWave sleepSpike activityThreshold Ca2Neurons