2019
Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain
Gallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y. Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain. Journal Of Nuclear Medicine 2019, 60: 1140-1146. PMID: 30877174, DOI: 10.2967/jnumed.118.219766.Peer-Reviewed Original ResearchConceptsTest-retest variabilityNondisplaceable distribution volumeOccipital cortexEnzyme 11β-hydroxysteroid dehydrogenase type 1White matterDistribution volumeTreatment of depressionDehydrogenase type 1Large cortical regionsPosttraumatic stress disorderHuman brainAdditional scansIntraclass correlation coefficientAge-related cognitive functionBolus administrationFrontal cortexCaudate nucleusAdipose tissueTime-activity curvesNovel radiotracersGlucocorticoid levelsParietal cortexCortical regionsPattern of uptakeType 1
2017
Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder
Worhunsky PD, Matuskey D, Gallezot JD, Gaiser EC, Nabulsi N, Angarita GA, Calhoun VD, Malison RT, Potenza MN, Carson RE. Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder. NeuroImage 2017, 148: 343-351. PMID: 28110088, PMCID: PMC5344702, DOI: 10.1016/j.neuroimage.2017.01.045.Peer-Reviewed Original Research
2010
Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14455-14459. PMID: 20660731, PMCID: PMC2922598, DOI: 10.1073/pnas.1002467107.Peer-Reviewed Original ResearchConceptsMiddle frontal cortexStop-signal reaction timeCocaine-dependent patientsWhole-brain linear regressionLonger stop-signal reaction timesFunctional MRI studyInhibitory controlInhibition-related activationBlood pressureIntravenous methylphenidatePeripheral biomarkersSignal reaction timeFrontal cortexStop-signal taskIndividualized treatmentHealthy individualsMRI studiesVentromedial prefrontal cortexSpecific neural mechanismsCocaine dependenceBiological markersPrefrontal cortexPatientsMethylphenidate responseSignal task