2023
Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[18F]flubatine PET study
Calakos K, Hillmer A, Anderson J, LeVasseur B, Baldassarri S, Angarita G, Matuskey D, Kapinos M, Zheng M, Huang Y, Cosgrove K. Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[18F]flubatine PET study. Neuropsychopharmacology 2023, 48: 683-689. PMID: 36681758, PMCID: PMC9938267, DOI: 10.1038/s41386-023-01535-1.Peer-Reviewed Original ResearchConceptsExecutive functionCholinergic systemWorse executive functionAcetylcholine levelsVerbal learningCognitive batteryPositron emission tomography brainCognitive dataAbstinent smokersCognitive functionCognitive deficitsCortical acetylcholine levelsEarly smoking cessationAcetylcholinesterase inhibitor physostigmineCognitionQuit attemptsNAChR sitesPhysostigmine administrationTomography brainSmoking statusSmoking cessationInhibitor physostigmineTreatment strategiesAgonist radioligandPhysostigmine challenge
2017
389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study
Esterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study. Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.Peer-Reviewed Original ResearchPreliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures
Davis MT, DellaGioia N, Matuskey D, Harel B, Maruff P, Pietrzak RH, Esterlis I. Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures. Journal Of Affective Disorders 2017, 218: 82-85. PMID: 28460315, PMCID: PMC6457447, DOI: 10.1016/j.jad.2017.04.064.Peer-Reviewed Original ResearchConceptsCogState measuresVerbal learningComputerized cognitive test batteryLower full-scale IQ scoresFull Scale IQ scoresCognitive test batteryCognitive test performanceMajor depressive disorderMagnitude of deficitsVisual attentionVisual memoryCognitive measuresExecutive functionCognitive functioningPsychomotor speedVisuospatial problemIntellectual functioningIQ scoresTest batteryCognitive deficitsTest performanceCognitive dysfunctionMemoryAssessment measuresDepressive disorder