2022
Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy
Korenblik R, Olij B, Aldrighetti LA, Hilal MA, Ahle M, Arslan B, van Baardewijk LJ, Baclija I, Bent C, Bertrand CL, Björnsson B, de Boer MT, de Boer SW, Bokkers RPH, Rinkes IHMB, Breitenstein S, Bruijnen RCG, Bruners P, Büchler MW, Camacho JC, Cappelli A, Carling U, Chan BKY, Chang DH, choi J, Font JC, Crawford M, Croagh D, Cugat E, Davis R, De Boo DW, De Cobelli F, De Wispelaere JF, van Delden OM, Delle M, Detry O, Díaz-Nieto R, Dili A, Erdmann JI, Fisher O, Fondevila C, Fretland Å, Borobia FG, Gelabert A, Gérard L, Giuliante F, Gobardhan PD, Gómez F, Grünberger T, Grünhagen DJ, Guitart J, Hagendoorn J, Heil J, Heise D, Herrero E, Hess GF, Hoffmann MH, Iezzi R, Imani F, Nguyen J, Jovine E, Kalff JC, Kazemier G, Kingham TP, Kleeff J, Kollmar O, Leclercq WKG, Ben SL, Lucidi V, MacDonald A, Madoff DC, Manekeller S, Martel G, Mehrabi A, Mehrzad H, Meijerink MR, Menon K, Metrakos P, Meyer C, Moelker A, Modi S, Montanari N, Navines J, Neumann UP, Peddu P, Primrose JN, Qu X, Raptis D, Ratti F, Ridouani F, Rogan C, Ronellenfitsch U, Ryan S, Sallemi C, Moragues JS, Sandström P, Sarriá L, Schnitzbauer A, Serenari M, Serrablo A, Smits MLJ, Sparrelid E, Spüntrup E, Stavrou GA, Sutcliffe RP, Tancredi I, Tasse JC, Udupa V, Valenti D, Fundora Y, Vogl TJ, Wang X, White SA, Wohlgemuth WA, Yu D, Zijlstra IAJ, Binkert CA, Bemelmans MHA, van der Leij C, Schadde E, van Dam RM. Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy. CardioVascular And Interventional Radiology 2022, 45: 1391-1398. PMID: 35790566, PMCID: PMC9458562, DOI: 10.1007/s00270-022-03176-1.Peer-Reviewed Original ResearchConceptsFuture liver remnant hypertrophyHepatic vein embolizationMulticenter prospective single-arm trialResectable colorectal cancer liver metastasesColorectal cancer liver metastasesProspective single-arm trialFeasibility of resectionCancer liver metastasesDisease-free survivalSingle-arm trialSmall FLRPrimary endpointSecondary endpointsFLR hypertrophyLiver metastasesOverall survivalProspective trialVein embolizationLiver functionSafety profileArm trialLiver volumeWeek 1Week 3Study centers
2013
Percutaneous Intraportal Application of Adipose Tissue–derived Mesenchymal Stem Cells Using a Balloon Occlusion Catheter in a Porcine Model of Liver Fibrosis
Avritscher R, Abdelsalam ME, Javadi S, Ensor J, Wallace MJ, Alt E, Madoff DC, Vykoukal JV. Percutaneous Intraportal Application of Adipose Tissue–derived Mesenchymal Stem Cells Using a Balloon Occlusion Catheter in a Porcine Model of Liver Fibrosis. Journal Of Vascular And Interventional Radiology 2013, 24: 1871-1878. PMID: 24144538, DOI: 10.1016/j.jvir.2013.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBalloon OcclusionBiomarkersBiopsyCell TrackingCells, CulturedEndovascular ProceduresEquipment DesignEthanolEthiodized OilGreen Fluorescent ProteinsHepatic VeinsLiverLiver Cirrhosis, ExperimentalMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsSus scrofaTime FactorsTransfectionVascular Access DevicesVenous PressureConceptsHepatic venous pressure gradientBalloon occlusion catheterOcclusion catheterMesenchymal stem cellsLiver fibrosisLarge animal modelIntraportal applicationEndovascular approachPortal veinAdipose tissueAnimal modelsExperimental animalsPercutaneous endovascular approachVenous pressure gradientTranscatheter arterial embolizationNovel endovascular approachStem cellsPortal hypertensionVascular complicationsArterial embolizationLiver injuryLiver damageBiopsy specimensSham injectionBalloon inflationUpdate on Portal Vein Embolization: Evidence-based Outcomes, Controversies, and Novel Strategies
May BJ, Talenfeld AD, Madoff DC. Update on Portal Vein Embolization: Evidence-based Outcomes, Controversies, and Novel Strategies. Journal Of Vascular And Interventional Radiology 2013, 24: 241-254. PMID: 23369559, DOI: 10.1016/j.jvir.2012.10.017.Peer-Reviewed Original ResearchConceptsPortal vein embolizationFuture liver remnantVein embolizationCurative hepatic resectionPortal blood flowNumber of patientsTumor-bearing liverRecent outcome dataEvidence-based outcomesPostoperative morbidityFLR hypertrophyHepatic resectionLiver remnantPatient outcomesBlood flowOutcome dataNovel strategyEmbolizationSurgeryTherapyOutcomesMorbidityResectionPatientsHypertrophy