2014
Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo
Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials 2014, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBiomarkersCollagenDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFibrin Tissue AdhesiveFibroblast Growth Factor 2Flow CytometryHumansImmunohistochemistryMaleMesenchymal Stem CellsMice, Inbred C57BLMiddle AgedNeovascularization, PhysiologicReal-Time Polymerase Chain ReactionRheologySubcutaneous TissueWound HealingConceptsAdipose-derived mesenchymal stromal cellsMesenchymal stromal cellsGranulation tissueStromal cellsPericyte marker NG2VE-cadherinWound healingPublic health problemMarkers of endotheliumDays of healingSubcutaneous injectionPresence of bFGFFibrin gelAmount of bFGFHAT-MSCsFibrin sealantWound sizeHealth problemsChronic woundsConfocal imaging analysisInsufficient angiogenesis
2000
The other side of the sun
Leffell D. The other side of the sun. The Lancet 2000, 356: 699. PMID: 11085686, DOI: 10.1016/s0140-6736(00)02625-8.Peer-Reviewed Original Research
1999
Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing
Kolenik S, McGovern T, Leffell D. Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing. Dermatologic Surgery 1999, 25: 303-307. PMID: 10417587, DOI: 10.1046/j.1524-4725.1999.08230.x.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryBovine collagen matrixMicrographic surgeryWound careControl groupWound healingMinority of patientsPostoperative wound healingSecond intention healingCollagen matrixManagement of defectsWound infectionDressing changesAdverse reactionsImmediate reconstructionAllergic reactionsComplete healingAnatomic sitesRapid wound healingSurgical defectsStudy woundsLarger studySecond intentionBiological dressingSurgery
1996
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
Gailani M, Ståhle-Bäckdahl M, Leffell D, Glyn M, Zaphiropoulos P, Undén A, Dean M, Brash D, Bale A, Toftgård R. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nature Genetics 1996, 14: 78-81. PMID: 8782823, DOI: 10.1038/ng0996-78.Peer-Reviewed Original ResearchConceptsSporadic basal cell carcinomasSingle-strand conformational polymorphismTumor suppressorDrosophila segment polarity geneSegment polarity genesHedgehog target genesPolarity genesDrosophila mutantsStrong homologyHuman homologueTarget genesMutational inactivationMutant transcriptsStrand conformational polymorphismNorthern blotSSCP variantsGenesNegative feedback mechanismSitu hybridizationConformational polymorphismNevoid basal cell carcinoma syndromeSuppressorAllelic lossInactivationMutationsMutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Hahn H, Wicking C, Zaphiropoulos P, Gailani M, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden A, Gillies S, Negus K, Smyth I, Pressman C, Leffell D, Gerrard B, Goldstein A, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale A. Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome. Cell 1996, 85: 841-851. PMID: 8681379, DOI: 10.1016/s0092-8674(00)81268-4.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsBasal Cell Nevus SyndromeBase SequenceChromosome MappingChromosomes, Human, Pair 9Cloning, MolecularDNA, ComplementaryDrosophilaDrosophila ProteinsExonsFemaleGene DeletionGene ExpressionGenes, Tumor SuppressorHumansIn Vitro TechniquesInsect HormonesIntronsMembrane ProteinsMolecular Sequence DataMutationPedigreeReceptors, Cell SurfaceSequence Homology, Nucleic AcidConceptsDrosophila segment polarity geneSegment polarity genesCertain cell typesDevelopmental abnormalitiesPolarity genesHuman homologStrong homologySporadic basal cell carcinomasHuman sequenceCosmid contigTumor suppressorLoss of heterozygosityCell typesGenesPatched geneChromosome 9q22.3Complete lossFunction contributesNevoid basal cell carcinoma syndromeMutation analysisBasal cell carcinoma syndromeAutosomal dominant disorderNBCCS patientsDrosophilaDominant disorder
1995
The Gorlin syndrome gene: a tumor suppressor active in basal cell carcinogenesis and embryonic development.
Bale A, Gailani M, Leffell D. The Gorlin syndrome gene: a tumor suppressor active in basal cell carcinogenesis and embryonic development. Proceedings Of The Association Of American Physicians 1995, 107: 253-7. PMID: 8624861.Peer-Reviewed Original Research