2014
Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities
Zhang J, Labaree D, Hochberg R. Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities. Chinese Chemical Letters 2014, 25: 567-570. DOI: 10.1016/j.cclet.2014.01.015.Peer-Reviewed Original Research
1999
7α-Iodo and 7α-Fluoro Steroids as Androgen Receptor-Mediated Imaging Agents
Labaree D, Hoyte R, Nazareth L, Weigel N, Hochberg R. 7α-Iodo and 7α-Fluoro Steroids as Androgen Receptor-Mediated Imaging Agents. Journal Of Medicinal Chemistry 1999, 42: 2021-2034. PMID: 10354410, DOI: 10.1021/jm990064o.Peer-Reviewed Original ResearchConceptsAndrogen receptorAndrogen-responsive reporter geneHigh androgenic activityImaging agentReceptor-mediated uptakeDHT 4Rat prostatic cytosolReceptor binding propertiesHigh affinityMale ratsRat prostateAndrogenic activityResponsive reporter geneProstatic cytosolDiagnostic imaging agentsReceptorsHigh binding activitySteroidsIodinated compoundBiological activityDegrees CHigher bindingMetabolic oxidationDHTBiological potency