2017
Rapid implementation of the repair-misrepair-fixation (RMF) model facilitating online adaption of radiosensitivity parameters in ion therapy
Kamp F, Carlson DJ, Wilkens JJ. Rapid implementation of the repair-misrepair-fixation (RMF) model facilitating online adaption of radiosensitivity parameters in ion therapy. Physics In Medicine And Biology 2017, 62: n285-n296. PMID: 28561011, DOI: 10.1088/1361-6560/aa716b.Peer-Reviewed Original ResearchHeavy Ion RadiotherapyHumansModels, BiologicalRadiation ToleranceRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessTime FactorsUncertainty
2016
Biologically optimized helium ion plans: calculation approach and its in vitro validation
Mairani A, Dokic I, Magro G, Tessonnier T, Kamp F, Carlson DJ, Ciocca M, Cerutti F, Sala PR, Ferrari A, Böhlen TT, Jäkel O, Parodi K, Debus J, Abdollahi A, Haberer T. Biologically optimized helium ion plans: calculation approach and its in vitro validation. Physics In Medicine And Biology 2016, 61: 4283-4299. PMID: 27203864, DOI: 10.1088/0031-9155/61/11/4283.Peer-Reviewed Original ResearchAlgorithmsCell Line, TumorCell SurvivalHeliumHumansRadioisotopesRadiotherapy Planning, Computer-AssistedRelative Biological Effectiveness
2015
Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra
Kamp F, Cabal G, Mairani A, Parodi K, Wilkens JJ, Carlson DJ. Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 557-568. PMID: 26460998, DOI: 10.1016/j.ijrobp.2015.07.2264.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAstrocytomaBrain NeoplasmsCell DeathCell SurvivalDNA Breaks, Double-StrandedDNA RepairHeavy Ion RadiotherapyHumansModels, BiologicalPhotonsRadiation ToleranceRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessConceptsRelative biological effectivenessCarbon ion therapyCarbon ionsIon therapyHeavy ion treatment planningMonte Carlo code FLUKAPrimary carbon ionsCarbon ion energyRadiation therapy beamsRBE valuesCarbon ion treatment plansRelevant RBE valuesRMF predictionsHeavy ionsIon energyDouble-strand break (DSB) yieldsRMF modelEnergy spectrumTherapy beamsSecondary fragmentsMonte Carlo damage simulationNuclear fragmentsBiological optimizationBiological effectivenessRBE predictions
2011
Tumor hypoxia is an important mechanism of radioresistance in hypofractionated radiotherapy and must be considered in the treatment planning process
Carlson DJ, Yenice KM, Orton CG. Tumor hypoxia is an important mechanism of radioresistance in hypofractionated radiotherapy and must be considered in the treatment planning process. Medical Physics 2011, 38: 6347-6350. PMID: 22149817, DOI: 10.1118/1.3639137.Peer-Reviewed Original ResearchMeSH KeywordsDose Fractionation, RadiationHumansModels, BiologicalNeoplasmsRadiation ToleranceRadiotherapy DosageRadiotherapy Planning, Computer-Assisted