2012
Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma
Siddon A, Lozovatsky L, Mohamed A, Hudnall SD. Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma. British Journal Of Haematology 2012, 158: 635-643. PMID: 22757777, DOI: 10.1111/j.1365-2141.2012.09206.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedBlotting, WesternCell Line, TumorDNA, ViralEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHerpesvirus 6, HumanHodgkin DiseaseHumansImmunohistochemistryLymphoma, FollicularMaleMiddle AgedPolymerase Chain ReactionReed-Sternberg CellsRoseolovirus InfectionsSclerosisYoung AdultConceptsNodular sclerosis Hodgkin lymphomaNodular sclerosis HLHHV-6 DNAEpstein-Barr virusHHV-6Hodgkin's lymphomaReed-Sternberg cellsPolymerase chain reactionRS cellsNSHL casesEBV-negative diseaseReactive lymphoid hyperplasiaClassical Hodgkin lymphomaBi-modal age distributionHHV-6 genomeYounger patientsInfectious etiologyLymphoid hyperplasiaPCR positivityYounger ageImmunohistochemistryMost casesConflicting resultsChain reactionCD30
2006
Anatomical mapping of human herpesvirus reservoirs of infection
Chen T, Hudnall SD. Anatomical mapping of human herpesvirus reservoirs of infection. Modern Pathology 2006, 19: 726-737. PMID: 16528368, DOI: 10.1038/modpathol.3800584.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnal CanalAutopsyCytomegalovirusDNA, ViralFemaleHerpesviridaeHerpesviridae InfectionsHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 7, HumanHerpesvirus 8, HumanHumansIntestinesMaleMiddle AgedNasal MucosaNervous SystemThyroid GlandConceptsHHV-6Whole blood specimensHSV-1Lymph nodesHHV-7Nasal mucosaAnatomic sitesHuman herpesvirusesHIV-AIDSActive herpesvirus infectionHSV-1 positivitySalivary glandsMajor anatomic sitesMiddle-aged malesTime of deathCardiac arrestHHV-8Adrenal glandElderly malesPrimary infectionHSV-2Urinary bladderHerpesvirus infectionAnatomical mappingBone marrow
2005
Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils
Hudnall SD, Ge Y, Wei L, Yang NP, Wang HQ, Chen T. Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils. Modern Pathology 2005, 18: 519-527. PMID: 15696119, DOI: 10.1038/modpathol.3800369.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDB-LymphocytesChildChild, PreschoolEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmunohistochemistryImmunophenotypingMaleMiddle AgedPalatine TonsilT-LymphocytesViral Matrix ProteinsViral ProteinsConceptsEpstein-Barr virusEBER-positive cellsT cellsHuman tonsilsNK cellsPlasma cellsEpithelial cellsB cellsBiology of EBVNK/T-cell lymphomaEpstein-Barr virus-infected cellsEBV latent protein EBNA1CD20-positive B cellsCD3-positive T cellsEarly Protein BZLF1Non-B cell typeNatural killer cellsRare T cellsT-cell lymphomaLMP1-positive cellsVirus-infected cellsMost tonsilsPlasmacytoid morphologyKiller cellsInterfollicular zones
2004
Hematologic differences in heterophile‐positive and heterophile‐negative infectious mononucleosis
Ventura KC, Hudnall SD. Hematologic differences in heterophile‐positive and heterophile‐negative infectious mononucleosis. American Journal Of Hematology 2004, 76: 315-318. PMID: 15282662, DOI: 10.1002/ajh.20119.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAnimalsAntibodies, HeterophileCattleChildChild, PreschoolCross ReactionsFemaleHerpesvirus 4, HumanHumansInfectious MononucleosisLatex Fixation TestsLeukocyte CountLeukopeniaLymphocyte CountLymphocytesLymphocytosisMaleMiddle AgedRetrospective StudiesConceptsEBV-positive patientsEBV-negative patientsAbsolute lymphocyte countInfectious mononucleosisAtypical lymphocytosisLymphocyte countEpstein-Barr virus infectionEBV-negative casesEBV-negative groupTotal WBC countAgglutination test resultsAtypical lymphocytesAbsolute lymphocytosisBlood countLeukocyte countWBC countHematologic parametersVirus infectionMononucleosisHematologic differencesPatientsLymphocytosisEBVCountCause
2003
Human herpesvirus 8 seroprevalence and viral load in healthy adult blood donors
Hudnall SD, Chen T, Rady P, Tyring S, Allison P. Human herpesvirus 8 seroprevalence and viral load in healthy adult blood donors. Transfusion 2003, 43: 85-90. PMID: 12519435, DOI: 10.1046/j.1537-2995.2003.00272.x.Peer-Reviewed Original ResearchConceptsHHV-8 seroprevalenceBlood donorsDonor bloodPrimary effusion B-cell lymphomaABO blood group BHigh HHV-8 seroprevalenceHuman herpesvirus 8 seroprevalenceLatent HHV-8 antigensHealthy adult blood donorsBlood donor unitsBuffy coat DNAHHV-8 antigensHHV-8 ORF26HHV-8 viremiaSensitive indirect immunofluorescenceGeometric mean titersAdult blood donorsHHV-8 antibodiesHHV-8 DNABlood-borne virusesHuman herpesvirus 8B-cell lymphomaBlood group BDonor blood samplesHuman tumor virus
2001
Composite nodular lymphocyte-predominance Hodgkin disease and gamma-heavy-chain disease: a case report and review of the literature.
Hudnall S, Alperin J, Petersen J. Composite nodular lymphocyte-predominance Hodgkin disease and gamma-heavy-chain disease: a case report and review of the literature. Archives Of Pathology & Laboratory Medicine 2001, 125: 803-7. PMID: 11371236, DOI: 10.5858/2001-125-0803-cnlphd.Peer-Reviewed Original ResearchConceptsNodular lymphocyte predominance Hodgkin's diseaseLymphocyte predominance Hodgkin's diseaseHodgkin's diseaseChain diseaseAutoimmune hemolytic anemiaB-cell natureB-cell lymphoproliferative processesComplete remissionGraves' diseaseLymph nodesCase reportLymphoproliferative processMonoclonal gammopathyHemolytic anemiaBone marrowUnique caseDiseaseClonal relationshipFurther treatment
2000
CD13-positive anaplastic large cell lymphoma of T-cell origin--a diagnostic and histogenetic problem.
Popnikolov N, Payne D, Hudnall S, Hawkins H, Kumar M, Norris B, Elghetany M. CD13-positive anaplastic large cell lymphoma of T-cell origin--a diagnostic and histogenetic problem. Archives Of Pathology & Laboratory Medicine 2000, 124: 1804-8. PMID: 11100061, DOI: 10.5858/2000-124-1804-cpalcl.Peer-Reviewed Original ResearchConceptsExtramedullary myeloid cell tumorAnaplastic large cell lymphomaT-cell originLarge cell lymphomaHistiocytic tumorsCell lymphomaCD30-positive anaplastic large cell lymphomaFlow cytometryExpression of CD13Complete remissionExtranodal sitesCytoplasmic CD3HLA-DRPrognostic implicationsCell tumorsDifferential diagnosisHistiocytic originHistogenetic problemsSurface antigenCD13 expressionVacuolated cytoplasmMalignant transformationCell expressionTumorsSurface markersMeasurement of estrogen receptors in intact cells by flow cytometry
Cao S, Hudnall S, Kohen F, Lu L. Measurement of estrogen receptors in intact cells by flow cytometry. Cytometry 2000, 41: 109-114. PMID: 11002266, DOI: 10.1002/1097-0320(20001001)41:2<109::aid-cyto5>3.0.co;2-7.Peer-Reviewed Original ResearchConceptsAnti-ER antibodiesDirect immunofluorescenceFlow cytometryIndirect immunofluorescenceEstrogen receptor levelsBreast cancer patientsER-negative MDAOutcome of treatmentHuman breast cancer cells MCF-7Anti-idiotypic antibodiesBreast cancer cells MCF-7Cancer cells MCF-7Flow cytometric analysisER immunostainingCells MCF-7Cancer patientsReceptor levelsEstrogen receptorER antibodyIntracellular antigensCytometric analysisTreatment of cellsTumor cellsAntibody clonesAntibodiesAcute myeloid leukemia associated with hemophagocytic syndrome and t(4;7)(q21;q36)
Kumar M, Boggino H, Hudnall S, Velagaleti G. Acute myeloid leukemia associated with hemophagocytic syndrome and t(4;7)(q21;q36). Cancer Genetics 2000, 122: 26-29. PMID: 11104028, DOI: 10.1016/s0165-4608(00)00268-5.Peer-Reviewed Original ResearchConceptsCases of HPSHemophagocytic syndromeMyeloid leukemiaClinical significanceMalignant processHematological malignanciesAcute myeloid leukemiaClonal karyotypic abnormalitiesClonal abnormalitiesFurther clonal evolutionKaryotypic abnormalitiesMalignancyNonclonal abnormalitiesAbnormalitiesClonal evolutionSyndromeLeukemiaCytogenetic studiesMicroscopic evidencePrognosisReactive processInfectionDiagnosisCasesKikuchi-Fujimoto Disease
Hudnall S. Kikuchi-Fujimoto Disease. American Journal Of Clinical Pathology 2000, 113: 761-764. PMID: 10874874, DOI: 10.1309/n4e2-78v9-qtfh-x4ff.Peer-Reviewed Original ResearchT‐gamma gene rearrangement and CMV mononucleosis
Mathew P, Hudnall S, Elghetany M, Payne D. T‐gamma gene rearrangement and CMV mononucleosis. American Journal Of Hematology 2000, 66: 64-66. PMID: 11426498, DOI: 10.1002/1096-8652(200101)66:1<64::aid-ajh1013>3.0.co;2-v.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralBlood CellsBone Marrow CellsClone CellsCytomegalovirusCytomegalovirus InfectionsDiagnosis, DifferentialFemaleGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorHumansImmunoglobulin MImmunophenotypingInfectious MononucleosisLymphoproliferative DisordersMiddle AgedT-Lymphocyte SubsetsViremiaConceptsT gamma gene rearrangementCMV infectionLymphoproliferative diseaseAcute CMV infectionGene rearrangementsAtypical lymphocytosisCMV mononucleosisCMV viremiaNight sweatsIgM serologyClinical featuresLymphoid aggregatesBlood countPeripheral bloodHemolytic anemiaImmune responseBone marrowWeight lossCytomegalovirusInfectionDiseaseMononucleosisViremiaSplenomegalyLymphocytosis
1998
Serologic and Molecular Evidence of Human Herpesvirus 8 Activation in Renal Transplant Recipients
Hudnall S, Rady P, Tyring S, Fish J. Serologic and Molecular Evidence of Human Herpesvirus 8 Activation in Renal Transplant Recipients. The Journal Of Infectious Diseases 1998, 178: 1791-1794. PMID: 9815236, DOI: 10.1086/314482.Peer-Reviewed Original ResearchConceptsRenal transplant patientsGeometric mean titersHealthy adultsTransplant patientsPolymerase chain reactionRenal transplant populationRenal transplant recipientsHIV-positive adultsHuman immunodeficiency virusViral DNATransplant recipientsTransplant groupTransplant populationMean titersImmunodeficiency virusImmunocompromised populationsSerum antibodiesKaposi's sarcomaPositive adultsSerologic resultsIndirect immunofluorescenceWhole bloodChain reactionAdultsPatientsDetection of human herpesvirus-8 DNA in Kaposi’s sarcomas from iatrogenically immunosuppressed patients
Rady P, Hodak E, Yen A, Memar O, Trattner A, Feinmesser M, David M, Hudnall S, Tyring S. Detection of human herpesvirus-8 DNA in Kaposi’s sarcomas from iatrogenically immunosuppressed patients. Journal Of The American Academy Of Dermatology 1998, 38: 429-437. PMID: 9520025, DOI: 10.1016/s0190-9622(98)70501-8.Peer-Reviewed Original ResearchConceptsKaposi's sarcomaHHV-8Polymerase chain reactionHHV-8 DNA detectionImmunosuppressed organ transplant patientsHuman herpesvirus 8 DNAOpen reading frame 26Different primary diseasesHHV-8 sequencesIatrogenic Kaposi's sarcomaOrgan transplant patientsHHV-8 DNAClassic Kaposi's sarcomaEndemic Kaposi's sarcomaFrame 26Nontransplant patientsImmunosuppressive therapyTransplant patientsAIDS-KSPrimary diseaseBiopsy specimensHigh prevalencePatientsNew herpesvirusSarcoma
1996
Spurious automated white cell count wiht Coulter STKS in the myelodysplastic syndromes suggests the presence of a red cell membrane defect
Elghetany M, Hudnall S. Spurious automated white cell count wiht Coulter STKS in the myelodysplastic syndromes suggests the presence of a red cell membrane defect. American Journal Of Hematology 1996, 52: 69-69. PMID: 8638626, DOI: 10.1002/(sici)1096-8652(199605)52:1<69::aid-ajh20>3.0.co;2-1.Peer-Reviewed Original Research
1993
Clonal heavy chain isotype switching within the proliferation centers of a small lymphocytic lymphoma: Implications regarding the origin of proliferation centers
Hudnall S, Berenson J. Clonal heavy chain isotype switching within the proliferation centers of a small lymphocytic lymphoma: Implications regarding the origin of proliferation centers. Human Pathology 1993, 24: 796-801. PMID: 8319958, DOI: 10.1016/0046-8177(93)90018-c.Peer-Reviewed Original Research
1987
B‐cell lymphoma in severe combined immunodeficiency not associated with the Epstein–Barr virus
Garcia C, Brown N, Schreck R, Stiehm E, Hudnall S. B‐cell lymphoma in severe combined immunodeficiency not associated with the Epstein–Barr virus. Cancer 1987, 60: 2941-2947. PMID: 2824020, DOI: 10.1002/1097-0142(19871215)60:12<2941::aid-cncr2820601216>3.0.co;2-a.Peer-Reviewed Original ResearchConceptsEpstein-Barr virus nuclear antigenB-cell lymphomaB-cell lymphoproliferative disordersEBV DNASevere combined immunodeficiencyLymphoproliferative disordersMalignant B-cell lymphomaEBV DNA probePrevention of EBVImmunoglobulin heavy chain gene rearrangementB-cell lymphoproliferationEpstein-Barr virusClonal B-cell lymphomaGene rearrangementsHeavy chain gene rearrangementClonal Ig gene rearrangementsChain gene rearrangementAntiviral chemoprophylaxisTransplant patientsSuch prophylaxisImmunodeficient patientsTumor cell DNAAnticomplement immunofluorescenceSitu cytohybridizationPatients