T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen.
LaSalle JM, Toneguzzo F, Saadeh M, Golan DE, Taber R, Hafler DA. T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. The Journal Of Immunology 1993, 151: 649-57. PMID: 7687620, DOI: 10.4049/jimmunol.151.2.649.Peer-Reviewed Original ResearchConceptsStaphylococcal enterotoxin BT cell clonesT cellsT cell presentationAnergy inductionCalcium fluxMHC classCell contactHuman T cell clonesCell interactionsT cell coculturesT cell responsesMHC class IIT cell interactionsT cell migrationIndividual T cellsSingle T cellsSubsequent anergyHLA-DRIndividual CD4Class IIAnergyEnterotoxin BSuperantigensSelf-Stimulation