2004
4 Molecular Mimicry in Multiple Sclerosis Role of MHC-Altered Peptide Ligands (MAPL)
Lim D, Hafler D. 4 Molecular Mimicry in Multiple Sclerosis Role of MHC-Altered Peptide Ligands (MAPL). 2004, 45-55. PMCID: PMC7151874, DOI: 10.1016/b978-044451271-0.50004-1.Peer-Reviewed Original ResearchMicrobial peptidesMolecular mimicryMimicry hypothesisMolecular mechanismsMultiple sclerosisMolecular mimicry hypothesisDisease entityMajor pathogenic mechanismAttractive hypothesisMimicryPeptide ligandsMyelin proteinsSingle disease entityPathogenic mechanismsMultiple sclerosis lesionsCross-reacting antigenDirect evidenceDisease stageT cellsPeptidesSclerosis lesionsProteinDifferent disordersImmunological studiesMechanism
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The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.
Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL. The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. The Journal Of Immunology 1988, 140: 2210-4. PMID: 2965183, DOI: 10.4049/jimmunol.140.7.2210.Peer-Reviewed Original ResearchConceptsMultiple sclerosisViral encephalitisImmune responseCentral nervous system immune responseSuppressor-inducer functionCentral nervous system tissuePlaque edgeAdjacent white matterIL-2R mAbNervous system tissueMultiple sclerosis lesionsAnti-2H4Anti-CD4Inflammatory cellsMS plaquesImmunohistochemical stainingWhite matterSclerosis lesionsEncephalitisPatientsCellsRare cellsCD8CD4Sclerosis