2016
Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells
Arterbery AS, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto SJ, Martinez M, Hafler DA, Kleinewietfeld M, Ekong UD. Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells. The Journal Of Immunology 2016, 196: 4040-4051. PMID: 27183637, PMCID: PMC4874532, DOI: 10.4049/jimmunol.1502276.Peer-Reviewed Original ResearchConceptsRegulatory T cellsIL-12IL-6T cellsSuppressive functionDe novo autoimmune hepatitisHuman regulatory T cellsNovo autoimmune hepatitisProinflammatory IL-12Th17 effector cellsTregs of patientsDifferentiation of TregsIL-17 cytokinesBlockade of IFNMonocyte/macrophage cellsLiver of subjectsAutoimmune hepatitisDominant cytokineProinflammatory IFNTH1-likeIL-17Treg phenotypeTreg dysfunctionEffector cellsInflammatory milieu
2014
Identification of Pathogenic IL-17 Producing FOXP3+ Tregs in Patients With De Novo Autoimmune Hepatitis.
Ekong U, Hill M, Edmunds C, Han G, Bhela S, Hafler D, Kleinewietfeld M. Identification of Pathogenic IL-17 Producing FOXP3+ Tregs in Patients With De Novo Autoimmune Hepatitis. Transplantation 2014, 98: 872-873. DOI: 10.1097/00007890-201407151-02977.Peer-Reviewed Original ResearchDe novo autoimmune hepatitisNovo autoimmune hepatitisAutoimmune hepatitisTregsFoxp3HepatitisPatients