2021
Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells
Tran TT, Rane CK, Zito CR, Weiss SA, Jessel S, Lucca L, Lu BY, Oria VO, Adeniran A, Chiang VL, Omay SB, Hafler DA, Kluger HM, Jilaveanu LB. Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells. Cancers 2021, 13: 1049. PMID: 33801444, PMCID: PMC7958624, DOI: 10.3390/cancers13051049.Peer-Reviewed Original ResearchPDCD4 expressionImproved survivalTumor-Associated Immune CellsTumor microenvironmentNeoplastic progressionBrain metastasis outcomesExtracranial metastatic diseaseMelanoma brain metastasesNatural killer cellsBrain metastasis samplesImmune cell infiltrationImmune cell subsetsMultiple tissue microarraysExpression of PDCD4Brain metastasesMetastatic diseaseClinical outcomesKiller cellsClinicopathological variablesIntracranial metastasesCell subsetsCell infiltrationCell death 4Immune cellsPrimary melanoma
1998
Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells
Mandelboim O, Kent S, Davis D, Wilson S, Okazaki T, Jackson R, Hafler D, Strominger J. Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 3798-3803. PMID: 9520447, PMCID: PMC19917, DOI: 10.1073/pnas.95.7.3798.Peer-Reviewed Original ResearchConceptsNatural killer cell activating receptorsT cellsNK cellsInterferon γ secretionSubset of CD8Target cellsHuman class I major histocompatibility complex (MHC) moleculesNatural killer cellsInterferon-gamma secretionGammadelta T cellsMajor histocompatibility complex moleculesAlphabeta T cellsClass I MHC moleculesClass I major histocompatibility complex moleculesTypes of lymphocytesMHC class IHistocompatibility complex moleculesI MHC moleculesT cell receptorEnhancement of proliferationΓ secretionGamma secretionNatural killerKiller cellsActivating receptors