1988
Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.
Hafler DA, Ritz J, Schlossman SF, Weiner HL. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. The Journal Of Immunology 1988, 141: 131-8. PMID: 2454256, DOI: 10.4049/jimmunol.141.1.131.Peer-Reviewed Original ResearchConceptsHuman anti-mouse antibodiesAnti-mouse responseAnti-mouse antibodiesHuman anti-mouse responseMultiple sclerosisChronic progressive multiple sclerosisPhase I clinical studyAnti-CD2 monoclonal antibodiesProgressive multiple sclerosisMore chronic diseasesT cell subpopulationsHuman immune responseT cell activationAcute immunosuppressionMAb infusionsT cell surfaceAnti-CD4Daily infusionsImmunologic responseImmunosuppressive effectsChronic diseasesIgG isotypeClinical studiesImmune responseLike antibodiesImmunosuppression with monoclonal antibodies in multiple sclerosis.
Hafler DA, Weiner HL. Immunosuppression with monoclonal antibodies in multiple sclerosis. Neurology 1988, 38: 42-7. PMID: 3260356.Peer-Reviewed Original ResearchConceptsHuman anti-mouse antibodiesChronic progressive multiple sclerosisAnti-T cell mAbsAnti-mouse antibodiesProgressive multiple sclerosisMAb infusionsMultiple sclerosisChronic diseasesT11 mAbPhase I clinical studyAnti-idiotypic activityMonoclonal antibody infusionMore chronic diseasesT cell subpopulationsAnti-mouse responseHuman immune responseAnti-idiotypic antibodiesHuman anti-mouse responseT cell activationAcute immunosuppressionT cell surfaceAntibody infusionImmunologic responseRepeated administrationIgG isotype
1986
Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12.
Hafler D, Fallis R, Dawson D, Schlossman S, Reinherz E, Weiner H. Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology 1986, 36: 777-84. PMID: 3486383, DOI: 10.1212/wnl.36.6.777.Peer-Reviewed Original ResearchConceptsHuman anti-mouse antibodiesAnti-mouse antibodiesDay 3Anti-T cell monoclonal antibodiesProgressive multiple sclerosis patientsPost-thymic T cellsMultiple sclerosis patientsMild allergic reactionsProgression of diseaseMonoclonal Antibodies ReactiveEffect of treatmentPhase one studyProgressive MSClinical effectsSclerosis patientsImmunologic responseBlood levelsImmunologic studiesPokeweed mitogenAllergic reactionsT cellsAntibody reactivePatientsDay 1Day 7