1988
Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.
Hafler DA, Ritz J, Schlossman SF, Weiner HL. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. The Journal Of Immunology 1988, 141: 131-8. PMID: 2454256, DOI: 10.4049/jimmunol.141.1.131.Peer-Reviewed Original ResearchConceptsHuman anti-mouse antibodiesAnti-mouse responseAnti-mouse antibodiesHuman anti-mouse responseMultiple sclerosisChronic progressive multiple sclerosisPhase I clinical studyAnti-CD2 monoclonal antibodiesProgressive multiple sclerosisMore chronic diseasesT cell subpopulationsHuman immune responseT cell activationAcute immunosuppressionMAb infusionsT cell surfaceAnti-CD4Daily infusionsImmunologic responseImmunosuppressive effectsChronic diseasesIgG isotypeClinical studiesImmune responseLike antibodies
1987
In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis
Hafler D, Weiner H. In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis. Annals Of Neurology 1987, 22: 89-93. PMID: 3498435, DOI: 10.1002/ana.410220121.Peer-Reviewed Original ResearchConceptsCentral nervous systemProgressive multiple sclerosisMultiple sclerosisBlood T cellsT cellsCerebrospinal fluidMurine monoclonal antibodiesSheep red blood cell receptorTreatment of MSPeripheral blood T cellsRed blood cell receptorsMonoclonal antibodiesCSF T cellsSerial lumbar puncturesPeripheral immune systemOngoing pathological processAnti-T4MS patientsDaily infusionsLumbar puncturePeripheral bloodInflammatory diseasesCSF specimensNervous systemImmune system