2007
Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction.
Martell BA, O'Connor PG, Kerns RD, Becker WC, Morales KH, Kosten TR, Fiellin DA. Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction. Annals Of Internal Medicine 2007, 146: 116-27. PMID: 17227935, DOI: 10.7326/0003-4819-146-2-200701160-00006.Peer-Reviewed Original ResearchConceptsChronic back painSubstance use disordersEfficacy of opioidsBack painMedication-taking behaviorUse disordersOpioid treatmentOpioid medicationsStudy qualityShort-term pain reliefCurrent substance use disorderCochrane Central RegisterLifetime substance use disorderControlled Clinical TrialsLong-term efficacyPoor study qualityEnglish-language studiesTransdermal opioidsOpioid prescribingPain reliefCentral RegisterDifferent opioidsReduced painClinical trialsNonsignificant reduction
2006
The Association Between Marijuana Smoking and Lung Cancer: A Systematic Review
Mehra R, Moore BA, Crothers K, Tetrault J, Fiellin DA. The Association Between Marijuana Smoking and Lung Cancer: A Systematic Review. JAMA Internal Medicine 2006, 166: 1359-1367. PMID: 16832000, DOI: 10.1001/archinte.166.13.1359.Peer-Reviewed Original ResearchConceptsLung cancerMarijuana smokingLung cancer risk factorsCancer risk factorsPotential adverse health outcomesPersons 18 yearsAdverse health outcomesFurther rigorous studiesEnglish-language studiesLung changesTobacco smokingTobacco smokersHistopathologic abnormalitiesHistopathologic findingsEmbase databasesPremalignant changesRisk factorsObservational studyMarijuana exposureMethodologic deficienciesTobacco useNineteen studiesSmokingTar exposureLack of adjustment