2019
Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth
Li X, He S, Tian Y, Weiss RM, Martin DT. Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth. Cellular Signalling 2019, 63: 109381. PMID: 31374291, DOI: 10.1016/j.cellsig.2019.109381.Peer-Reviewed Original ResearchMeSH KeywordsButadienesCarcinoma, Transitional CellCell Line, TumorCell MovementCell SurvivalDrug Resistance, NeoplasmDrug SynergismEnzyme InhibitorsGene Expression Regulation, NeoplasticGlycoproteinsHumansHydrazinesMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1NitrilesQuinoxalinesUrinary Bladder NeoplasmsConceptsChemoresistant bladder cancerBladder cancer cellsBladder cancerInterleukin-6Clinical outcomesMultidrug resistanceGemcitabine-resistant bladder cancer cellsBladder cancer cell growthMajor treatment obstacleMetastatic bladder cancerPI3K/Akt/mTOR signalingCancer cellsResistant bladder cancer cellsPoor clinical outcomeAkt/mTOR SignalingSynergistic inhibitionNovel therapeutic strategiesPotential therapeutic targetMEK/ERK signalingCancer cell growthRaf/MEK/ERK signalingRole of gp130Therapeutic strategiesTreatment obstaclesTherapeutic target
2015
Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat
Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Martin DT, Nakamura K, Honda M, Inoue K, Saito M. Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat. PLOS ONE 2015, 10: e0133798. PMID: 26308715, PMCID: PMC4550428, DOI: 10.1371/journal.pone.0133798.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdrenergic alpha-1 Receptor AntagonistsAnimalsChemokine CXCL1Fibroblast Growth Factor 2IndolesInterleukin-6MaleMalondialdehydeProstateProstatic HyperplasiaRatsRats, Inbred SHRReceptors, Adrenergic, alpha-1Regional Blood FlowTransforming Growth Factor beta1Tumor Necrosis Factor-alphaConceptsProstatic blood flowEffects of silodosinBasic fibroblast growth factorAlpha1A-adrenoceptor antagonistInterleukin-6Blood flowBlood pressureProstatic hyperplasiaHypertensive ratsTissue levelsWKY ratsΑ-SMATGF-β1Twelve-week-old male SHRsVentral prostateCytokine-induced neutrophil chemoattractant-1Selective alpha1A-adrenoceptor antagonistAlpha-smooth muscle actinGrowth factor beta 1Neutrophil chemoattractant-1Spontaneously Hypertensive RatsBenign prostatic enlargementBody weight ratioWistar-Kyoto ratsMorphological abnormalities