Germline Mutations in BRCA1 and BRCA2 in Breast-Ovarian Families From a Breast Cancer Risk Evaluation Clinic
Martin A, Blackwood MA, Antin-Ozerkis D, Shih HA, Calzone K, Colligon TA, Seal S, Collins N, Stratton MR, Weber BL, Nathanson KL. Germline Mutations in BRCA1 and BRCA2 in Breast-Ovarian Families From a Breast Cancer Risk Evaluation Clinic. Journal Of Clinical Oncology 2001, 19: 2247-2253. PMID: 11304778, DOI: 10.1200/jco.2001.19.8.2247.Peer-Reviewed Original ResearchConceptsOvarian cancerEvaluation clinicGermline mutationsStudy groupLow-penetrance susceptibility genesBreast Cancer Linkage ConsortiumOvarian cancer familiesBreast cancer diagnosisYounger average ageClinical parametersBreast cancerAverage ageMutation statusHereditary breastMultivariate analysisRegion of BRCA1CancerCancer familiesBreastClinicCancer diagnosisProportion of familiesBRCA2Strongest predictorDirect sequencing