Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation
Meeker D, Kim J, Vezina P. Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation. Brain Research 1998, 812: 260-264. PMID: 9813358, DOI: 10.1016/s0006-8993(98)00941-x.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate receptor activationDepletion of dopamineMetabotropic glutamate receptorsGlutamate receptor activationMicroinjection of salineGroups of ratsNon-lesioned animalsContribution of dopamineMGluR agonistBilateral microinjectionDA levelsMGluR activationDA neurotransmissionGlutamate receptorsNucleus accumbensMicroinjection sitesLocomotor activityReceptor activationRatsEnhanced locomotionDopamineGeneration of locomotionAMPHNAccSaline