Escaping the stem cell compartment: Sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations
Zhang W, Remenyik E, Zelterman D, Brash D, Wikonkal N. Escaping the stem cell compartment: Sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 13948-13953. PMID: 11707578, PMCID: PMC61147, DOI: 10.1073/pnas.241353198.Peer-Reviewed Original ResearchThe use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines.
Peng X, Won J, Rutherford T, Fujii T, Zelterman D, Pizzorno G, Sapi E, Leavitt J, Kacinski B, Crystal R, Schwartz P, Deisseroth A. The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. Cancer Research 2001, 61: 4405-13. PMID: 11389068.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsCytomegalovirusCytosine DeaminaseFemaleFlucytosineFluorouracilGene ExpressionGenetic TherapyGenetic VectorsHumansInhibitory Concentration 50Lac OperonMembrane GlycoproteinsMiceMice, NudeMicrofilament ProteinsNucleoside DeaminasesOvarian NeoplasmsPhosphoproteinsPromoter Regions, GeneticTumor Cells, CulturedUrinary Bladder NeoplasmsXenograft Model Antitumor AssaysConceptsL-plastin promoterBladder cancer cell linesNormal ovarian cellsCancer cell linesOvarian cancer cellsTumor nodulesAdenoviral vectorCell linesNormal peritoneal mesothelial cellsOvarian cellsCD vectorSKOV-3 ovarian cancer cell lineFibroblast cell lineReplication-incompetent adenoviral vectorCancer cellsOvarian cancer cell linesNormal peritoneal cellsPeritoneal mesothelial cellsMouse xenograft modelCytosine deaminase geneSurgical specimensOvarian cancerTumor-specific gene expressionPeritoneal cellsOVCAR-5