1992
Mechanisms of Retraction Pocket Formation in the Pediatric Tympanic Membrane
Ruah C, Schachern P, Paparella M, Zelterman D. Mechanisms of Retraction Pocket Formation in the Pediatric Tympanic Membrane. JAMA Otolaryngology - Head & Neck Surgery 1992, 118: 1298-1305. PMID: 1449688, DOI: 10.1001/archotol.1992.01880120024005.Peer-Reviewed Original ResearchConceptsSerous otitis mediaOtitis mediaPurulent otitis mediaTemporal bonePosterosuperior quadrantTympanic membraneType of cholesteatomaImportant risk factorPars tensaEpidemiological natureRetraction pocket formationPars flaccidaYears 6 monthsGreater inflammatory reactionClinical findingsRisk factorsInflammatory reactionCholesteatomaPocket formationAgeBoneChildrenTensaQuadrantDisease
1991
Middle Ear Fluid Lysozyme Source in Experimental Pneumococcal Otitis Media
Nonomura N, Giebink G, Harada T, Zelterman D, Juhn S. Middle Ear Fluid Lysozyme Source in Experimental Pneumococcal Otitis Media. Annals Of Otology Rhinology & Laryngology 1991, 100: 593-596. PMID: 2064274, DOI: 10.1177/000348949110000715.Peer-Reviewed Original ResearchConceptsMiddle ear fluidPneumococcal otitis mediaInflammatory cellsOtitis mediaInflammatory mediatorsAcute pneumococcal otitis mediaExperimental pneumococcal otitis mediaAcute otitis mediaChronic otitis mediaImportant inflammatory mediatorsMiddle ear inflammationMiddle ear infectionMiddle ear environmentFuture therapeutic interventionsMucosal epithelial cellsMiddle ear epitheliumSource of lysozymeEar inflammationEar infectionsInflammatory responseEar fluidDirect stimulationTherapeutic interventionsStreptococcus pneumoniaeMiddle earEarly Biochemical Events in Pneumococcal Otitis Media: Arachidonic Acid Metabolites in Middle Ear Fluid
Nonomura N, Giebink G, Harada T, Zelterman D, Juhn S. Early Biochemical Events in Pneumococcal Otitis Media: Arachidonic Acid Metabolites in Middle Ear Fluid. Annals Of Otology Rhinology & Laryngology 1991, 100: 385-388. PMID: 1850967, DOI: 10.1177/000348949110000507.Peer-Reviewed Original ResearchConceptsMiddle ear fluidArachidonic acid metabolitesEar fluidLeukotriene B4Acid metabolitesPneumococcal otitis mediaSubsequent inflammatory responseInflammatory cell chemotaxisStreptococcus pneumoniae organismsMiddle ear inoculationInflammatory cellsOtitis mediaF1 alphaInflammatory responseProstaglandin E2Pneumoniae organismsArachidonate metabolitesArachidonic acidCell chemotaxisEar inoculationEarly biochemical eventsSignificant increaseInitial stimulusHoursMetabolites