2024
Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections
Li K, Chaguza C, Stamp J, Chew Y, Chen N, Ferguson D, Pandya S, Kerantzas N, Schulz W, Initiative Y, Hahn A, Ogbunugafor C, Pitzer V, Crawford L, Weinberger D, Grubaugh N. Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections. PLOS Computational Biology 2024, 20: e1012469. PMID: 39288189, PMCID: PMC11432881, DOI: 10.1371/journal.pcbi.1012469.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle-nucleotide polymorphismsAssociation studiesWhole-genome sequencingAmino acid changesSingle nucleotide polymorphismsPairs of substitutionsViral copiesEpistasis testsGenome sequenceGenetic variationSpike geneAcid changesViral genomeNucleotide polymorphismsSARS-CoV-2Detect interactionsHost factorsVirus copiesCopyInfection dynamicsRT-qPCRPolymorphismOmicron BASARS-CoV-2 infection
2010
Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta-Analysis
Weinberger DM, Harboe ZB, Sanders EA, Ndiritu M, Klugman KP, Rückinger S, Dagan R, Adegbola R, Cutts F, Johnson HL, O'Brien KL, Scott JA, Lipsitch M. Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta-Analysis. Clinical Infectious Diseases 2010, 51: 692-699. PMID: 20715907, PMCID: PMC2927802, DOI: 10.1086/655828.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseRisk of deathCarriage prevalenceHost factorsAssociation of serotypesLower comorbidity scorePooled effect estimatesStudy-specific estimatesNasopharyngeal carriage prevalenceCase fatality ratioSerotype-specific dataHigher carriage prevalenceRandom-effects methodBacteremic pneumoniaPooled RRComorbidity scorePneumococcal pneumoniaPneumococcal diseaseMeningitis patientsDisease outcomePotential confoundingPneumoniaSerotype 14Epidemiologic measuresMeta-Analysis