2019
Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychoses
Hess JL, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, Tooney P, Schall U, Gardiner E, Beveridge NJ, Scott RJ, Yasawardene S, Perera A, Mendis J, Carr V, Kelly B, Cairns M, Unit T, Tsuang MT, Glatt SJ. Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychoses. Schizophrenia Research 2019, 217: 124-135. PMID: 31391148, PMCID: PMC6997041, DOI: 10.1016/j.schres.2019.07.036.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderGene Expression ProfilingHumansPsychotic DisordersSchizophreniaTranscriptomeConceptsGene modulesSZ casesGene co-expression network analysisCo-expression network analysisGene expression profilesGene expression alterationsChromatin regulationChromatin remodelingNineteen genesGene networksTranscriptomic abnormalitiesDisorder-specific changesGene expressionExpression profilesBiological processesImmune signalingExpression alterationsTranscriptomic signaturesGenesReactive oxygenUnaffected comparison subjectsMajor psychosesOxidative stressBD casesApoptosis
2016
Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia
Hess JL, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, Tooney P, Schall U, Gardiner E, Beveridge NJ, Scott RJ, Yasawardene S, Perera A, Mendis J, Carr V, Kelly B, Cairns M, Unit T, Tsuang MT, Glatt SJ. Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia. Schizophrenia Research 2016, 176: 114-124. PMID: 27450777, PMCID: PMC5026943, DOI: 10.1016/j.schres.2016.07.006.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersGene Expression ProfilingHumansMachine LearningMicroarray AnalysisModels, StatisticalPrefrontal CortexPsychotic DisordersSchizophreniaTranscriptomeConceptsGene co-expression modulesMicroarray dataCo-expression modulesInnate immune gene expressionRelated gene setsImmune gene expressionTranscription regulatorsNetwork-based analysisGene setsBiological functionsGene expressionRegulatory factorsPostmortem prefrontal cortexMicroarray technologyCell typesTop hitsHigh-throughput assessmentGenesTissue functionBlood tissuePostmortem brain tissueGenetic risk factorsImmunologic genesMicroarray literatureDysregulation
2013
Blood‐based gene‐expression predictors of PTSD risk and resilience among deployed marines: A pilot study
Glatt SJ, Tylee DS, Chandler SD, Pazol J, Nievergelt CM, Woelk CH, Baker DG, Lohr JB, Kremen WS, Litz BT, Tsuang MT, Investigators M. Blood‐based gene‐expression predictors of PTSD risk and resilience among deployed marines: A pilot study. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 162: 313-326. PMID: 23650250, DOI: 10.1002/ajmg.b.32167.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral bloodBlood cellsPTSD casesHigh-risk individualsPeripheral blood samplesPanel of biomarkersExpression levelsGene expression levelsPredictive biomarker panelPredictive panelHigh riskBlood samplesBiomarker panelEarly interventionGene expression predictorsTrauma exposurePTSD riskPilot studyBloodImmune genesIndependent samplesFull-length gene transcriptsPTSDRisk