2019
Dynamic Network Activation of Hypothalamic MCH Neurons in REM Sleep and Exploratory Behavior
Blanco-Centurion C, Luo S, Spergel DJ, Vidal-Ortiz A, Oprisan S, Van den Pol AN, Liu M, Shiromani PJ. Dynamic Network Activation of Hypothalamic MCH Neurons in REM Sleep and Exploratory Behavior. Journal Of Neuroscience 2019, 39: 4986-4998. PMID: 31036764, PMCID: PMC6670248, DOI: 10.1523/jneurosci.0305-19.2019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingCalciumExploratory BehaviorFemaleHypothalamic HormonesHypothalamusMaleMelaninsMiceNeuronsOptical ImagingPituitary HormonesSleep, REMConceptsMelanin-concentrating hormoneRapid eye movement (REM) sleepMCH neuronsEye movement sleepREM sleepHypothalamic neuronsMovement sleepHypothalamic melanin-concentrating hormone (MCH) neuronsMelanin-concentrating hormone (MCH) neuronsNeuropeptide melanin-concentrating hormoneHypothalamic MCH neuronsIndividual hypothalamic neuronsMost brain neuronsFunctional activity mapsExploratory behaviorNon-REM sleepCalcium indicator GCaMP6Single neuron activityHormone neuronsNetwork activationBrain neuronsElectrophysiology studySame neuronsQuiet wakingIndicator GCaMP6s
2009
Innervation of Gonadotropin-Releasing Hormone Neurons by Peptidergic Neurons Conveying Circadian or Energy Balance Information in the Mouse
Ward DR, Dear FM, Ward IA, Anderson SI, Spergel DJ, Smith PA, Ebling FJ. Innervation of Gonadotropin-Releasing Hormone Neurons by Peptidergic Neurons Conveying Circadian or Energy Balance Information in the Mouse. PLOS ONE 2009, 4: e5322. PMID: 19390688, PMCID: PMC2669176, DOI: 10.1371/journal.pone.0005322.Peer-Reviewed Original ResearchConceptsGnRH neuronsVasoactive intestinal peptidePeptidergic neuronsGonadotropin-Releasing Hormone NeuronsGnRH secretory systemVIP-IR fibersGonadotropin-releasing hormoneHypothalamic peptide systemsHormone neuronsBasal forebrainIntestinal peptideHypothalamic neuropeptidesPeptidergic fibersReproductive axisTransgenic miceModulatory inputsNeuronsCircadian timing informationPeptidergic signalsMetabolic statusMiceCircadian informationInnervationSignificant proportionPeptide system