1993
Differential modulation by extracellular ATP of carotid chemosensory responses
Spergel D, Lahiri S. Differential modulation by extracellular ATP of carotid chemosensory responses. Journal Of Applied Physiology 1993, 74: 3052-3056. PMID: 8366007, DOI: 10.1152/jappl.1993.74.6.3052.Peer-Reviewed Original ResearchConceptsCarotid bodyO2 chemoreceptionCarotid chemosensory responsesChemosensory responsesChemosensory dischargeATP administrationNeurotransmitter levelsPentobarbital sodiumATP receptorsNicotinic receptorsTyrode's solutionSimilar dose dependenceExtracellular ATPNicotineInitial stimulationDifferential modulationReceptorsSurface receptorsHypoxiaDose dependenceResponseChemoreceptionInfusionMetabolic Substrate Dependence of Carotid Chemosensory Responses To Stop-Flow Evoked Hypoxia and to Nicotine
Spergel D. Metabolic Substrate Dependence of Carotid Chemosensory Responses To Stop-Flow Evoked Hypoxia and to Nicotine. Advances In Experimental Medicine And Biology 1993, 337: 221-225. PMID: 7906483, DOI: 10.1007/978-1-4615-2966-8_31.ChaptersMeSH KeywordsAnimalsCarotid BodyCatsGlucoseGlutamatesGlutamic AcidHypoxiaIn Vitro TechniquesNicotinePerfusionConceptsCarotid body preparationCarotid bodyMetabolic substratesCarotid chemosensory responsesMM glucoseProgressive deteriorationBody preparationChemosensory responsivenessGlutamateChemosensory responsesSaline solutionAmino acidsTricarboxylic acid cycle intermediatesResponsivenessCellular energy productionATP generationGlucoseCycle intermediatesNicotineHypoxiaEffects of Haloperidol on Cat Carotid Body Chemoreception in Vitro
Morelli L, Iturriaga R, Spergel D, Data P. Effects of Haloperidol on Cat Carotid Body Chemoreception in Vitro. Advances In Experimental Medicine And Biology 1993, 337: 295-299. PMID: 8109412, DOI: 10.1007/978-1-4615-2966-8_41.ChaptersConceptsEffects of haloperidolCarotid body chemoreceptionD2-dopaminergic antagonistsRelease of neurotransmittersRole of dopamineChemosensory responsesCat CBCB chemoreceptionExcitatory rolePutative neurotransmittersChemoreceptionCO2 chemoreceptionDopaminergic antagonistsExogenous dopamineChemosensory activityHaloperidolHypothesis statesDopamineNeurotransmittersVitroLow pHVitro9Cell1
1992
Intracellular pH and oxygen chemoreception in the cat carotid body in vitro
Iturriaga R, Rumsey WL, Lahiri S, Spergel D, Wilson DF. Intracellular pH and oxygen chemoreception in the cat carotid body in vitro. Journal Of Applied Physiology 1992, 72: 2259-2266. PMID: 1629081, DOI: 10.1152/jappl.1992.72.6.2259.Peer-Reviewed Original Research
1991
In vitro perfused-superfused cat carotid body for physiological and pharmacological studies
Iturriaga R, Rumsey WL, Mokashi A, Spergel D, Wilson DF, Lahiri S. In vitro perfused-superfused cat carotid body for physiological and pharmacological studies. Journal Of Applied Physiology 1991, 70: 1393-1400. PMID: 1903380, DOI: 10.1152/jappl.1991.70.3.1393.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCarotid BodyCatsChemoreceptor CellsFemaleHypoxiaIn Vitro TechniquesMaleNicotinePerfusionSodium CyanideConceptsChemosensory dischargeCarotid bodyPentobarbital sodium-anesthetized catsWhole carotid sinus nerveCarotid sinus nerveInjections of nicotineCarotid body preparationCat carotid bodyRestoration of flowDose-dependent mannerSinus nerveNormoxic perfusionPerfusate PO2Pharmacological stimuliPerfusate flowInitial responsivenessTyrode's solutionPharmacological studiesCarotid bifurcationPerfusionCO2 stimulusBasal activityChemosensory responsesNicotineBody preparation