2005
Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons.
Shimshek DR, Bus T, Grinevich V, Single FN, Mack V, Sprengel R, Spergel DJ, Seeburg PH. Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons. Endocrinology 2005, 20: 219-31. PMID: 16099814, DOI: 10.1210/me.2005-0262.Peer-Reviewed Original ResearchConceptsAMPA receptorsNMDA receptorsGnRH secretionMale miceN-methyl-D-aspartate receptorsLimbic system neuronsSerum testosterone levelsIsoxazolepropionic acid (AMPA) receptorsIonotropic glutamate receptorsNormal litter sizeMale sexual behaviorGnRH neuronsSeptal neuronsSystem neuronsOvarian morphologyGlutamate receptorsSeptal areaTestosterone levelsControl littermatesMale littermatesPup retrievalMajor subtypesTestis weightMaternal aggressionAcid receptors
1994
Glutamate Modulates [Ca2+]i and Gonadotropin-Releasing Hormone Secretion in Immortalized Hypothalamic GT1-7 Neurons
Spergel D, Krsmanovic L, Stojilkovic S, Catt K. Glutamate Modulates [Ca2+]i and Gonadotropin-Releasing Hormone Secretion in Immortalized Hypothalamic GT1-7 Neurons. Neuroendocrinology 1994, 59: 309-317. PMID: 7911229, DOI: 10.1159/000126672.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCells, CulturedCycloleucineExcitatory Amino Acid AntagonistsFura-2GlutamatesGlutamic AcidGonadotropin-Releasing HormoneHypothalamusInositol PhosphatesMiceMice, TransgenicNeuronsNeurotoxinsReceptors, AMPAReceptors, GlutamateReceptors, N-Methyl-D-AspartateSpectrometry, FluorescenceConceptsDichlorokynurenic acidGnRH secretionMK-801Immortalized hypothalamic GT1-7 neuronsGonadotropin-Releasing Hormone SecretionOxo-4-isoxazolepropanoic acidAMPA/kainate antagonistGT1-7 cell lineAction of glutamateReceptor subtype agonistsNMDA receptor antagonistConcentration-dependent riseGT1-7 neuronsGT1-7 cellsKainate antagonistSubtype agonistsHormone secretionHypothalamic neuronsReceptor antagonistGlutamate actionSecretory responseNMDA receptorsGlycine siteCyclopentanedicarboxylic acidNeuroendocrine regulation