2002
Codon‐improved Cre recombinase (iCre) expression in the mouse
Shimshek DR, Kim J, Hübner MR, Spergel DJ, Buchholz F, Casanova E, Stewart AF, Seeburg PH, Sprengel R. Codon‐improved Cre recombinase (iCre) expression in the mouse. Genesis 2002, 32: 19-26. PMID: 11835670, DOI: 10.1002/gene.10023.Peer-Reviewed Original ResearchConceptsDifferent mammalian cell linesMammalian codon usageHigh CpG contentCre activityMammalian cell linesEstrogen receptor hormoneCre fusion proteinGenetic experimentsDNA recombinationEpigenetic silencingCodon usageCoding sequenceCpG contentCre geneFunctional analysisFusion proteinCre recombinase expressionReceptor hormoneAdministration of tamoxifenRecombinase expressionCre recombinaseTemporal controlICreCre expressionCell lines
1995
Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells.
Bagnato A, Tecce R, Moretti C, Di Castro V, Spergel D, Catt K. Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells. Clinical Cancer Research 1995, 1: 1059-66. PMID: 9816080.Peer-Reviewed Original ResearchConceptsOvarian carcinoma cellsHuman ovarian carcinoma cellsET-1ETA receptorsEndothelin-1Carcinoma cellsTumor cellsCell linesGrowth factorCertain ovarian tumorsET-1 participatesReceptor-mediated actionsOVCA 433 cellsOvarian tumor cell linesCalcium signalingDose-dependent increaseRadioligand binding studiesOvarian tumor cellsAutocrine growth factorOvarian cancer cellsSites/cellBasal growth rateAuthentic ET-1BQ-123ET receptors