Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus.
Settleman J, DiMaio D. Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 9007-9011. PMID: 2848252, PMCID: PMC282651, DOI: 10.1073/pnas.85.23.9007.Peer-Reviewed Original ResearchConceptsBovine papillomavirus type 1 E2Simian virus 40 early regionTransactivation of genesCultured mammalian cellsHybrid viral genomesSimian virus 40 virionsMouse C127 cellsSimian virus 40 large tumor antigenBovine papillomavirus type 1Large tumor antigenPapillomavirus type 1E5 mutantsAcute cellular responseRegulatory genesMammalian cellsControl regionEfficient transactivationForeign genesReporter geneType 1 geneWild-type virusC127 cellsE5 geneTumorigenic transformationCellular responses