Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin
Stavoe AK, Nelson JC, Martínez-Velázquez LA, Klein M, Samuel AD, Colón-Ramos DA. Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin. Genes & Development 2012, 26: 2206-2221. PMID: 23028145, PMCID: PMC3465741, DOI: 10.1101/gad.193409.112.Peer-Reviewed Original ResearchConceptsN-terminal domainActin cytoskeletonUnique N-terminal domainNeurodevelopmental programsSpecific subcellular domainsDistinct subcellular compartmentsN-terminal motifSynaptic vesicle clusteringIndividual cellular responsesNetrin signalsThermotaxis behaviorSubcellular compartmentsVesicle clusteringSubcellular domainsCellular responsesSynaptic vesiclesNetrinProtein 1IsoformsPresynaptic regionCytoskeletonMotifPresynaptic sitesVesiclesNeurodevelopmental responseNetrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton
Stavoe AK, Colón-Ramos DA. Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton. Journal Of Cell Biology 2012, 197: 75-88. PMID: 22451697, PMCID: PMC3317799, DOI: 10.1083/jcb.201110127.Peer-Reviewed Original ResearchConceptsActive zone proteinsActin cytoskeletonUNC-40Synaptic vesiclesSynapse assemblyVesicle clusteringCED-10/Rac1CED-5/DOCK180Receptor UNC-40/DCCPresynaptic regionUNC-40/DCCNetrin receptor UNC-40/DCCZone proteinSynaptic vesicle clusteringSeparate pathways downstreamRole of netrinsCED-5MIG-10Subcellular localizationRac GTPasePathways downstreamCytoskeletonCell migrationNetrinVesicles