2020
Identification of an Amygdala–Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions
Veldhuizen MG, Farruggia MC, Gao X, Nakamura Y, Green BG, Small DM. Identification of an Amygdala–Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions. Journal Of Neuroscience 2020, 40: 5051-5062. PMID: 32371606, PMCID: PMC7314406, DOI: 10.1523/jneurosci.2618-19.2020.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmygdalaFemaleHumansMaleNeural PathwaysTaste PerceptionThalamusYoung AdultConceptsTaste intensity perceptionHealthy human participantsFunctional magnetic resonanceVentral posterior medial thalamusPosterior medial thalamusIntensity ratingsMedial dorsalMedial thalamusInhibitory outputInhibitory inputsPeripheral sourcesMagnetic resonanceInhibitory influenceIntensity perceptionCentral circuitsGustatory factorsIndividual variationDynamic causal modeling analysisConnectivity strengthAmygdalaMultiple tastantsGustatory systemMean intensity ratingsTaste intensity ratingsAmygdala response
2012
Flavor is in the brain
Small DM. Flavor is in the brain. Physiology & Behavior 2012, 107: 540-552. PMID: 22542991, DOI: 10.1016/j.physbeh.2012.04.011.Peer-Reviewed Original ResearchAcute stress potentiates brain response to milkshake as a function of body weight and chronic stress
Rudenga KJ, Sinha R, Small DM. Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. International Journal Of Obesity 2012, 37: 309-316. PMID: 22430303, PMCID: PMC3381866, DOI: 10.1038/ijo.2012.39.Peer-Reviewed Original ResearchConceptsBody mass indexFunctional magnetic resonance imagingChronic stressOrbitofrontal cortexRight amygdalaBody weightPalatable foodAcute stressBasal cortisol levelsBrain responsesAmygdala responseMagnetic resonance imagingStress-related eatingMilkshake receiptPalatable milkshakeObese womenOverweight womenMass indexRight amygdala responseOFC responsesPotentiates responsesCortisol levelsLeft amygdalaResonance imagingVentral striatum
2005
Monetary Incentives Enhance Processing in Brain Regions Mediating Top-down Control of Attention
Small DM, Gitelman D, Simmons K, Bloise SM, Parrish T, Mesulam M. Monetary Incentives Enhance Processing in Brain Regions Mediating Top-down Control of Attention. Cerebral Cortex 2005, 15: 1855-1865. PMID: 15746002, DOI: 10.1093/cercor/bhi063.Peer-Reviewed Original ResearchConceptsSpatial expectancyVisual spatial attentionNon-directional cuesCurrent behavioral goalsControl of attentionTarget detection taskFaster reaction timesInferior parietal lobulePosterior cingulate cortexDifferent incentive conditionsValid cuesCentral cuesSpatial attentionMotivational mechanismsNeural processingMotivational incentivesUnimodal cortexBehavioral goalsLimbic mechanismsParietal lobuleAttention networkDetection taskCingulate cortexRelationship of activationIncentive conditions