2012
Altered hypothalamic response to food in smokers 1 , 2 , 3
Geha PY, Aschenbrenner K, Felsted J, O'Malley SS, Small DM. Altered hypothalamic response to food in smokers 1 , 2 , 3. American Journal Of Clinical Nutrition 2012, 97: 15-22. PMID: 23235196, PMCID: PMC3522134, DOI: 10.3945/ajcn.112.043307.Peer-Reviewed Original ResearchConceptsWeight changeBrain responsesFunctional MRILong-term weight changeAltered brain responsesTasteless control solutionMilk shakeEnergy-dense foodsGroup of ageSmoking statusSmoking cessationSmoking influencesHypothalamic responseNonsmokersSmokersVentral striatumWeight gainBMIHypothalamusGreater responseResponseFoodStudy 1ThalamusGroupAcute stress potentiates brain response to milkshake as a function of body weight and chronic stress
Rudenga KJ, Sinha R, Small DM. Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. International Journal Of Obesity 2012, 37: 309-316. PMID: 22430303, PMCID: PMC3381866, DOI: 10.1038/ijo.2012.39.Peer-Reviewed Original ResearchConceptsBody mass indexFunctional magnetic resonance imagingChronic stressOrbitofrontal cortexRight amygdalaBody weightPalatable foodAcute stressBasal cortisol levelsBrain responsesAmygdala responseMagnetic resonance imagingStress-related eatingMilkshake receiptPalatable milkshakeObese womenOverweight womenMass indexRight amygdala responseOFC responsesPotentiates responsesCortisol levelsLeft amygdalaResonance imagingVentral striatum
2003
Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
Small DM, Jones-Gotman M, Dagher A. Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. NeuroImage 2003, 19: 1709-1715. PMID: 12948725, DOI: 10.1016/s1053-8119(03)00253-2.Peer-Reviewed Original ResearchConceptsDopamine releasePositron emission tomography scanEmission tomography scanHealthy human volunteersHunger/fullnessFavorite mealAmount of dopamineDorsal putamenStriatum correlatesTomography scanHealthy subjectsCaudate nucleusPleasantness ratingsHuman volunteersVentral striatumScan subjectsStriatumHungry stateSignificant reductionSignificant changesPET dataMealParametric mapsSubjectsCorrelates