2020
Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sørensen J, Cador M, Fioramonti X, Tschöp MH, Layé S, Venance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism 2020, 31: 773-790.e11. PMID: 32142669, PMCID: PMC7250662, DOI: 10.1016/j.cmet.2020.02.010.Peer-Reviewed Original ResearchConceptsDopamine receptor subtype 2Lipoprotein lipaseReceptor subtype 2Energy-rich dietDopaminergic transmissionMesocorticolimbic systemDietary triglyceridesSubtype 2Reward deficitsReward circuitMetabolic signaturesWeight gainCompulsive feedingFood cuesTriglyceridesGenetic riskBrain responsesNew mechanistic basisCompulsive behaviorsNeuronsNovel mechanismMechanistic basisDysfunction
2016
Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity
Kroemer NB, Small DM. Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity. Physiology & Behavior 2016, 162: 37-45. PMID: 27085908, PMCID: PMC4971522, DOI: 10.1016/j.physbeh.2016.04.020.Peer-Reviewed Original ResearchConceptsFood-related stimuliBrain responsesReward-related learningReward sensitivityReward deficiencyReduced reward sensitivityPrimary food rewardReward receiptMilkshake receiptStriatal responsesReward deficitsFood rewardSubjective valueReinforcement learning frameworkRewardDopamine signalingFood anticipationDorsal striatumAnhedoniaAnticipatoryDopaminergic regionsStimuliConsummatory responsesAlternative viewLearning