2021
Post-traumatic olfactory loss and brain response beyond olfactory cortex
Pellegrino R, Farruggia MC, Small DM, Veldhuizen MG. Post-traumatic olfactory loss and brain response beyond olfactory cortex. Scientific Reports 2021, 11: 4043. PMID: 33597627, PMCID: PMC7889874, DOI: 10.1038/s41598-021-83621-2.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexOlfactory impairmentOlfactory cortexFunctional anosmiaPost-traumatic olfactory lossPrimary olfactory areasWhole-brain responsesBrain responsesGray matter densityHigher-order areasOlfactory lossPiriform cortexHead traumaHealthy controlsOlfactory areasOdorless stimuliOlfactory functionMediodorsal thalamusCortical areasVentromedial prefrontal cortexCingulate cortexFrontal operculumCortexAnterior insulaPrefrontal cortex
2020
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signatures
2013
Decreased food pleasure and disrupted satiety signals in chronic low back pain
Geha P, deAraujo I, Green B, Small DM. Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain 2013, 155: 712-722. PMID: 24384160, DOI: 10.1016/j.pain.2013.12.027.Peer-Reviewed Original ResearchConceptsChronic low back painCLBP patientsLow back painHealthy controlsBack painSugary drinksFat calorie intakeHedonic perceptionSatiety signalsCalorie intakePatientsIntake testFood pleasureFunctional brainAd libitumPotential mechanismsPainObesityIntakeStructural alterationsPhysiological mechanismsHedonic ratingsAlterationsDrinksSensory evaluation