Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition
Yadav D, Zigáčková D, Zlobina M, Klumpler T, Beaumont C, Kubíčková M, Vaňáčová Š, Lukavsky P. Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition. Nucleic Acids Research 2019, 48: 2091-2106. PMID: 31875226, PMCID: PMC7038937, DOI: 10.1093/nar/gkz1163.Peer-Reviewed Original ResearchConceptsDsRNA binding proteinSpecific mRNA targetsGroove sideMinor groove recognitionCytoplasmic mRNA levelsMRNA decayMRNA transportTranslational controlLoop anchorsMRNA targetsMinor groove sideMajor groove sideStaufen1Helix α1Sequence featuresDsRNABinding proteinGroove recognitionPhosphodiester backboneSpecific recognitionGuanine baseMRNA levels