2024
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α
Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett A, Diano S, Huang Y. Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. Diabetologia 2024, 67: 724-737. PMID: 38216792, PMCID: PMC10904493, DOI: 10.1007/s00125-023-06073-5.Peer-Reviewed Original ResearchConceptsTen-eleven translocationMuscle insulin sensitivityRNA-seqPGC-1aRegulation of muscle insulin sensitivityType 2 diabetesAnalysis of RNA-seqResponse to environmental cuesGenome-wide expression profilingWild-typeHFD-fedHFD-induced insulin resistanceHigh-fat diet (HFD)-inducedExpression levelsMaintenance of glucoseSkeletal muscle insulin sensitivityAccession numbersSkeletal muscleEnhanced glucose toleranceFamily dioxygenasesMitochondrial respirationSkeletal muscle of humansEnvironmental cuesMitochondrial functionBiological processes
2023
Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A
Yin Z, You S, Zhang S, Zhang L, Wu B, Huang X, Lu S, Cao L, Zhang Y, Li D, Zhang X, Liu J, Sun Y, Zhang N. Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A. Biomedicine & Pharmacotherapy 2023, 166: 115228. PMID: 37557013, DOI: 10.1016/j.biopha.2023.115228.Peer-Reviewed Original ResearchConceptsMitochondrial pathway of apoptosisRegulate protein ubiquitinationPathway of apoptosisE3 ubiquitin ligaseVascular endothelial injuryDeath of vascular endothelial cellsEndothelial injuryMitochondrial pathwayUbiquitin ligaseWWP2 overexpressionProteasome pathwayProtein ubiquitinationBcl-2/BaxBiological processesWWP2Vascular endotheliumATP5ALipid-lowering drugsUbiquitinEffect of atorvastatinImproving vascular endothelial functionVascular endothelial functionDamaged vascular endotheliumVascular endothelial cellsMechanism of atorvastatin