Tuft cells are key mediators of interkingdom interactions at mucosal barrier surfaces
Strine MS, Wilen CB. Tuft cells are key mediators of interkingdom interactions at mucosal barrier surfaces. PLOS Pathogens 2022, 18: e1010318. PMID: 35271673, PMCID: PMC8912186, DOI: 10.1371/journal.ppat.1010318.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInterkingdom interactionsTuft cellsCell biologyImmune responseMicrobial activationMicrobial sensingCell abundanceMucosal barrier surfacesAntiviral adaptive immune responsesType 2 immune responsesCell heterogeneityExquisite specificityMucosal barrier integrityAdaptive immune responsesMurine norovirusHuman healthKey orchestratorsMicrobial infectionsPathogenic bacteriaBroad intraFlavivirus replicationKey mediatorContext of coinfectionTissue repairImmune evasionRestriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice
Sharon AJ, Filyk HA, Fonseca NM, Simister RL, Filler RB, Yuen W, Hardman BK, Robinson HG, Seo JH, Rocha-Pereira J, Welch I, Neyts J, Wilen CB, Crowe SA, Osborne LC. Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice. Journal Of Virology 2022, 96: e02065-21. PMID: 35107369, PMCID: PMC8941907, DOI: 10.1128/jvi.02065-21.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaliciviridae InfectionsIntestinal MucosaMiceNorovirusSTAT1 Transcription FactorT-LymphocytesVirus ReplicationConceptsAntiviral T cell responsesT cell responsesSTAT1-deficient miceSystemic viral infectionCell responsesViral replicationViral infectionTissue damageViral-induced tissue damageVirus-induced tissue damageAltered T-cell responsesLimited viral replicationT cell immunopathologyOngoing inflammatory responseAdaptive immune cellsUncontrolled viral replicationBreakdown of toleranceImmune-mediated pathologyHost-directed mechanismViral componentsAntiviral CD4Lethal immunopathologyInfectious insultsImmune activationImmunological tolerance