Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease
Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS. Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease. Journal Of Clinical Investigation 2018, 128: 5110-5122. PMID: 30137026, PMCID: PMC6205411, DOI: 10.1172/jci120453.Peer-Reviewed Original ResearchConceptsPaneth cell defectsCD susceptibility genesSusceptibility genesCell defectsDisease-relevant phenotypesTranscriptional analysisCellular phenotypesApoptosis inhibitorCell-specific knockoutDisease subjectsFull-thickness ileumDistinct pathwaysCrohn's disease subjectsComplex inflammatory diseasePPARγ agonist rosiglitazoneCrypt base cellsEnvironmental risk factorsPaneth cellsGenesSelective downregulationCigarette smokingCrohn's diseasePhenotypeRelevant environmental exposuresCD subjects