2023
Age-associated features of norovirus infection analysed in mice
Kennedy E, Aggarwal S, Dhar A, Karst S, Wilen C, Baldridge M. Age-associated features of norovirus infection analysed in mice. Nature Microbiology 2023, 8: 1095-1107. PMID: 37188813, PMCID: PMC10484054, DOI: 10.1038/s41564-023-01383-1.Peer-Reviewed Original ResearchConceptsViral uptakeWild-type neonatal miceCortisone acetate administrationAdaptive immune responsesInterferon-stimulated gene expressionIntestinal tuft cellsSeverity of infectionAbsence of interferonAge-associated variabilityAge-associated featuresMNoV infectionAcetate administrationViral exposureAntibody responseEnteric infectionsNeonatal miceInfected damsNorovirus infectionHigh burdenImmune responsePersistent infectionViral RNA accumulationIleal absorptionJuvenile miceAdult mice
2019
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis
Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW. A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell Host & Microbe 2019, 25: 845-857.e5. PMID: 31130511, PMCID: PMC6622463, DOI: 10.1016/j.chom.2019.04.005.Peer-Reviewed Original ResearchConceptsNS1 secretionTuft cellsIFN-λ responseAnti-capsid antibodiesMNoV infectionAcute infectionIntestinal infectionsLack of inductionPersistent infectionNorovirus pathogenesisCaspase-3 cleavageIFN responseInfectionSecretionViral nonstructural proteinsIFNProtein 1/2Viral proteinsMurine norovirusNS1Lower percentageNonstructural proteinsCellsLow numberVaccination