Connectome-based models can predict early symptom improvement in major depressive disorder
Ju Y, Horien C, Chen W, Guo W, Lu X, Sun J, Dong Q, Liu B, Liu J, Yan D, Wang M, Zhang L, Guo H, Zhao F, Zhang Y, Shen X, Constable RT, Li L. Connectome-based models can predict early symptom improvement in major depressive disorder. Journal Of Affective Disorders 2020, 273: 442-452. PMID: 32560939, DOI: 10.1016/j.jad.2020.04.028.Peer-Reviewed Original ResearchConceptsMajor depressive disorderSymptom improvementAntidepressant treatmentMDD patientsDepressive disorderTreatment outcomesEarly symptom improvementIndividual therapeutic responseInitial MR scansUntreated MDD patientsResting-state functional connectivity patternsFirst-line treatmentThree-month time pointTime pointsAntidepressant treatment outcomeBaseline functional connectivityHamilton Rating ScaleSeverity of depressionResting-state connectivityFunctional connectivity patternsResting-state fMRI dataDifferent time pointsTherapeutic responseClinical practiceFunctional brain networks