Featured Publications
Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
Jian J, Tian Q, Hettinghouse A, Zhao S, Liu H, Wei J, Grunig G, Zhang W, Setchell K, Sun Y, Overkleeft H, Chan G, Liu C. Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. EBioMedicine 2016, 13: 212-224. PMID: 27789271, PMCID: PMC5264254, DOI: 10.1016/j.ebiom.2016.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDisease Models, AnimalFibroblastsGaucher DiseaseGlucosylceramidaseHSP70 Heat-Shock ProteinsHumansIntercellular Signaling Peptides and ProteinsLysosome-Associated Membrane GlycoproteinsLysosomesMiceMice, KnockoutPhenotypeProgranulinsProtein AggregatesProtein BindingRecombinant ProteinsStress, PhysiologicalConceptsGaucher diseaseLysosomal storage diseaseStorage diseaseCommon lysosomal storage diseaseNew therapeutic interventionsΒ-glucocerebrosidaseProgranulin insufficiencyAnimal modelsTherapeutic interventionsDiseasePGRNDisease phenotypePatient fibroblastsGCaseComplex-associated proteinsLysosomal localizationHSP70DeficiencyAssociation Between Progranulin and Gaucher Disease
Jian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, Wang G, Chen Y, Liang F, Overkleeft HS, Saunders-Pullman R, Chan GL, Liu CJ. Association Between Progranulin and Gaucher Disease. EBioMedicine 2016, 11: 127-137. PMID: 27515686, PMCID: PMC5049935, DOI: 10.1016/j.ebiom.2016.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesAnimalsCase-Control StudiesDisease Models, AnimalEnzyme ActivationFemaleGaucher DiseaseGene FrequencyGenetic Association StudiesGenotypeHumansIntercellular Signaling Peptides and ProteinsLysosomesMaleMiceMice, KnockoutMiddle AgedMutationPhenotypePolymorphism, Single NucleotideProgranulinsProtein TransportConceptsGD patientsHealthy controlsGaucher diseaseGRN genePGRN KO miceSerum PGRN levelsPGRN-deficient miceHealthy control samplesSerum levelsPGRN levelsGaucher-like cellsKO miceTherapeutic effectRecombinant PGRNGeneral populationPatientsAnimal modelsBone marrowGBA1 geneLysosomal localizationProgranulin geneNull micePGRNDiseaseMice
2018
Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease
Jian J, Chen Y, Liberti R, Fu W, Hu W, Saunders-Pullman R, Pastores G, Chen Y, Sun Y, Grabowski G, Liu C. Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease. EBioMedicine 2018, 28: 251-260. PMID: 29396296, PMCID: PMC5835567, DOI: 10.1016/j.ebiom.2018.01.022.Peer-Reviewed Original ResearchConceptsGD patientsHealthy controlsGaucher diseaseDownstream moleculesExpression of CHI3L1Serum CHI3L1Serum levelsPGRN levelsTherapeutic effectClinical biomarkersPatientsPotential biomarkersNull miceCHI3L1ProgranulinElevated levelsBiomarkersWhole-genome microarraysDiseaseCHIT1Genome microarraysNovel regulatorImmunohistochemistryLevelsMice
2009
Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With &agr;7&bgr;1 Integrin
Wang L, Zheng J, Du Y, Huang Y, Li J, Liu B, Liu C, Zhu Y, Gao Y, Xu Q, Kong W, Wang X. Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With &agr;7&bgr;1 Integrin. Circulation Research 2009, 106: 514-525. PMID: 20019333, DOI: 10.1161/circresaha.109.202762.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsAntigens, CDAorta, ThoracicBecaplerminCarotid Artery InjuriesCatheterizationCell DifferentiationCells, CulturedExtracellular MatrixExtracellular Matrix ProteinsGene Knockdown TechniquesGenetic VectorsGlycoproteinsIntegrin alpha ChainsIntegrinsMaleMatrilin ProteinsMuscle ContractionMuscle ProteinsMuscle, Smooth, VascularMyocytes, Smooth MusclePhenotypePlatelet-Derived Growth FactorProtein Interaction MappingProto-Oncogene Proteins c-sisRatsRats, Sprague-DawleyRecombinant Fusion ProteinsRNA, Small InterferingConceptsVascular smooth muscle cellsCartilage oligomeric matrix proteinEffects of COMPContractile phenotypeFocal adhesion assemblyVSMC differentiation marker genesAdenoviral overexpressionSmooth muscle cellsNormal vascular smooth muscle cellsVSMC phenotype switchingDifferentiation marker genesActin fiber organizationMuscle cellsAdhesion assemblyVascular extracellular matrixVSMC contractile phenotypeMarker genesDifferentiated stateRat vascular smooth muscle cellsPhenotype switchingPlatelet-derived growthVSMC adhesionMatrix proteinsVSMC dedifferentiationSmall interfering
2007
RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer*
Kong L, Yu X, Bai X, Zhang W, Zhang Y, Zhao W, Jia J, Tang W, Zhou Y, Liu C. RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer*. Journal Of Biological Chemistry 2007, 282: 26381-26391. PMID: 17616526, DOI: 10.1074/jbc.m702195200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCaspase 3Caspase 8Cell Line, TransformedCell Line, TumorCell Transformation, ViralCellular SenescenceCyclin DCyclinsElectrophoresis, Gel, Two-DimensionalFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHeLa CellsHuman papillomavirus 16HumansMiceMice, NudeNeoplasm TransplantationNuclear ProteinsOncogene Proteins, ViralPapillomavirus E7 ProteinsPhenotypeProto-Oncogene Proteins c-mycRepressor ProteinsRetinoblastoma ProteinRetinoblastoma-Binding Protein 4RNA, Small InterferingTumor Suppressor Protein p53Uterine Cervical DysplasiaUterine Cervical NeoplasmsConceptsCervical cancerH8 cellsCyclin D1Critical mediatorHuman papillomavirus infectionCervical cancer CaSki cellsTumor formationCervical cancer-derived cell linesCervical intraepithelial neoplasiaHuman papillomavirus type 16Papillomavirus type 16Cancer-derived cell linesSenescence-like phenotypePapillomavirus infectionIntraepithelial neoplasiaEnzyme caspase-3Cervical carcinogenesisType 16Nude miceCaSki cellsCancerTumor suppressor retinoblastomaOncogenic genesProtein 4Cell proliferation